HilD inhibitor C26

Chemical Structure : HilD inhibitor C26

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货号: PC-24403Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

HilD inhibitor C26 is a specific small molecule inhibitor of S. Typhimurium transcriptional regulator HilD with IC50 of 16.9 uM and binds to HilD with an apparent Kd of 30.2 uM, inhibits the secretion of SipA with IC50 of 29.2 uM.
C26 shows no effect on the thermal stability of HilC.
C26 inhibnits the DNA binding activity of HilD, whereas no effect on HilC activity.
C26 binds to the HilD homodimer to inhibit its binding to PhilA.
C26 blocked the expression of SipA, SctE, and SctP in whole cells, targets the regulatory pathway of Salmonella pathogenicity islands (SPIs) and reduces invasion into host cells.
C26 has an advantageous activity spectrum among S. Typhimurium clinical isolates, regardless of their source of isolation, sequence type, and antibiotic resistance profile.

物理化学性质&存储条件

分子量	397.29
分子式	C16H17BrN2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(benzo[d][1,3]dioxol-5-ylmethyl)-2-(((5-bromothiophen-2-yl)methyl)(methyl)amino)acetamide

参考文献

1. Boudrioua A, et al. Sci Adv. 2025 Apr 11;11(15):eadr5235.