Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-28632	XDS-23 LasI/LasR inhibitor	XDS-23 is a selective biofilm inhibitor with IC50 of 1.26 uM for inhibiting biofilm in P. aeruginosa PAO1, inhibits LasI/LasR System (las) and Pseudomonas Quinolone Signal System (pqs), suppresses the production of key virulence factors including elastase, pyocyanin, and extracellular polysaccharides, exhibits synergistic antibacterial activity and can enhance the efficacy of multiple antibiotics in both in vitro and in vivo.
PC-28631	LasR-IN-1 LasR inhibitor	LasR-IN-1 (Cpmpound 9g) is a potent quorum sensing (QS) system LasR inhibitor, inhibits QS by modulating the expression of virulence factors or by targeting LasR, shows anti-bacterial activity with MIC of 28.13 μM against P. aeruginosa.
PC-28617	Aurachin D Mtb Cyt-bd inhibitor	Aurachin D is a smal molecule Mycobacterium tuberculosis (Mtb) cytochrome bd oxidase (Cyt-bd) inhibitor, exhibits inhibitory effects against Gram-positive bacteria and fungi with IC50 value of 0.1 μM against Escherichia coli and IC50 ranging from 0.13 to 33 μM against Mycobacterium tuberculosis, blocks the electron transfer process, disrupts the respiratory chain and energy metabolism of pathogens.
PC-28610	Minocycline Antibiotic	Minocycline is a tetracycline antibiotic with neuroprotective, antiapoptotic, anti-inflammatory and antimicrobial effects, inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, also is a hypoxia-inducible factor (HIF)-1α inhibitor.
PC-28584	S-thanatin Antimicrobial peptide	S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity, inhibits the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, binds negatively charged LPS and anionic lipid, ihhibits membrane respiration, exhaustes the intracellular potential, and releases periplasmic material, leding to cell death.
PC-28583	Thanatin TFA Antimicrobial, LPS transport inhibitor	Thanatin TFA is a 21-residue inducible insect defense peptide within antimicrobial activity against fungi and some Gram-positive bacteria with MIC of 0.6-20 uM, disrupts bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase, inhibits LPS transport (Lpt) LptC-LptA interaction, disrupting the assembly of the Lpt protein machinery.
PC-28582	Thanatin Antimicrobial, LPS transport inhibitor	Thanatin is a 21-residue inducible insect defense peptide within antimicrobial activity against fungi and some Gram-positive bacteria with MIC of 0.6-20 uM, disrupts bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase, inhibits LPS transport (Lpt) LptC-LptA interaction, disrupting the assembly of the Lpt protein machinery.
PC-28531	S. aureus ClpC activator Cpd-8 S. aureus ClpC activator	S. aureus ClpC activator Cpd-8 is a small-molecule activator of the Staphylococcus aureus ClpC/ClpP AAA+ protease with EC50 of 12 uM, binds to ClpC N-terminal domain (NTD), induces ClpC/ClpP-independent toxicity in Staphylococcus aureus.
PC-28530	S. aureus ClpC activator Cpd-10 S. aureus ClpC activator	S. aureus ClpC activator Cpd-10 is a small-molecule activator of the Staphylococcus aureus ClpC/ClpP AAA+ protease with EC50 of 4.4 uM, induces ClpC/ClpP-independent toxicity in Staphylococcus aureus
PC-28495	Kasugamycin hydrochloride Antibiotic	Kasugamycin hydrochloride (Ksg) is a small ribosomal subunit-targeting antibiotic, binds to the bacterial 30S ribosomal subunit and inhibits canonical translation initiation, possesses anti-infective activity.
PC-28494	Kasugamycin Antibiotic	Kasugamycin (Ksg) is a small ribosomal subunit-targeting antibiotic, binds to the bacterial 30S ribosomal subunit and inhibits canonical translation initiation, possesses anti-infective activity.
PC-28393	NDM-552 PBP2 inhibitor	NDM-552 is a Gram-positive selective antibacterial agent that potentially targets penicillin-binding protein 2 (PBP2)-associated cell wall biosynthesis, exhibits activity against Gram-positive pathogens including S. aureus, Enterococcus faecium, and Staphylococcus epidermidis with MIC of 1-2 ug/mL.

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