| Cat. No. |
Product Name |
Information |
| PC-28183 |
DDD00079282
Mtb GuaB inhibitor
|
DDD00079282 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB, MtbIMPDH) with Ki of 0.22 uM, does not inhibit human IMPDH, shows antitubercular activity against Mtb H37Rv with MIC of 2 uM. |
| PC-28182 |
Q151
GuaB2 inhibitor
|
Q151 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2, MtbIMPDH2) with Ki app of 18 nM, does not inhibit human IMPDH2. |
| PC-28179 |
Mtb GuaB2 inhibitor G9
GuaB2 inhibitor
|
Mtb GuaB2 inhibitor G9 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2) with IC50 of 0.94 nM, and potent MIC against virulent Mtb H37Rv (IC50=58 nM). |
| PC-28150 |
Ozenoxacin
Antibiotic
|
Ozenoxacin (T-3912) is a quinolone-class antibiotic inhibiting DNA gyrase and topoisomerase IV, shows potent antibacterial activity against anaerobic and aerobic, gram-positive and -negative bacteria, has demonstrates excellent in vitro activity against MRSA and methicillin-resistant Staphylococcus epidermidis (MRSE), including quinolone-resistant strains. |
| PC-28122 |
Ceforanide
Antibiotic
|
Ceforanide (BL-S786R, BL-S 786) is a long-acting parenteral cephalosporin with broad-spectrum activity in vitro against 453 clinical isolates, inhibits >75% of isolates of Escherichia coli, Klebsiella spp., Proteus mirabilis, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae at 3.12 ug/mL. |
| PC-28119 |
CpxRA inhibitor Cpx26
CpxRA inhibitor
|
CpxRA inhibitor Cpx26 is a small-molecule CpxRA phosphatase inhibitor with EC50 of 1.1 uM, significantly inhibits Uropathogenic Escherichia coli swimming motility, biofilm formation, and adhesion to bladder epithelial cells. |
| PC-28084 |
DnaK inhibitor M7
DnaK inhibitor
|
DnaK inhibitor M7 is a small molecule inhibitor of bacterial Hsp70 protein DnaK ATPase, inhibits DnaK-mediated ATP hydrolysis with IC50 of 8.4 uM, likely engages the substrate-binding pocket of DnaK, induces accumulation of σ-32 without affecting protein translation, effectively inhibits the growth of E. coli AS19 and some Gram-positive bacteria, including Staphylococcus aureus and Bacillus cereus. |
| PC-28034 |
N-butyryl-L-homoserine lactone
Quorum-sensing molecule
|
N-Butanoyl-L-homoserine lactone (C4-HSL) is a Pseudomonas aeruginosa quorum-sensing signal molecule, blocks qurom sensing and inhibits biofilm formation in Pseudomonas aeruginosa, also is a cleavable ADC linker for synthesis of ADCs. |
| PC-28033 |
3OC12-HSL
Quorum-sensing molecule
|
3OC12-HSL is a P. aeruginosa quorum-sensing molecule, triggers quorum-sensing signal cascade, interacts with signal receptor-transcription factors LasR and QscR. |
| PC-27995 |
BVL3572S
Mtb HisC/AlaA inhibitor
|
BVL3572S is a potent bactericidal compound potently inhibits Mtb growth (MIC90=1.7 uM, Mtb H37Rv) and is bactericidal, inhibits two essential pyridoxal phosphate (PLP)-dependent aminotransferases HisC and AlaA, disrupting L-His and L-Ala biosynthesis. |
| PC-27987 |
Obafluorin
Antibiotic, ThrRS inhibitor
|
Obafluorin is a beta-lactone antibiotic with activity against both Gram-positive and -negative pathogens, inhibits E. coli and P. fluorescens threonyl-tRNA synthetase (ThrRS, TRS) with IC50 of 35 nM and 4.3 nM respectively. |
| PC-27731 |
Afabicin
FabI inhibitor
|
Afabicin (Debio 1450, AFN-1720) is an antibiotic targets the staphylococcal enoyl-acyl carrier protein reductase (FabI) and exhibits selective potent antibacterial activity against staphylococcal species, including MRSA, |
