DDD00079282

Chemical Structure : DDD00079282

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货号: PC-28183Not For Human Use, Lab Use Only.

DDD00079282 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB, MtbIMPDH) with Ki of 0.22 uM, does not inhibit human IMPDH, shows antitubercular activity against Mtb H37Rv with MIC of 2 uM.

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生物&药学活性

DDD00079282 is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB, MtbIMPDH) with Ki of 0.22 uM, does not inhibit human IMPDH, shows antitubercular activity against Mtb H37Rv with MIC of 2 uM.

物理化学性质&存储条件

分子量	291.33
分子式	C12H13N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1H-indazol-6-yl)-3,5-dimethyl-1H-pyrazole-4-sulfonamide

参考文献

1. Yumi Park, et al. ACS Infect Dis. 2017 Jan 13;3(1):18-33.

DDD00079282

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物理化学性质&存储条件

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DDD00079282

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