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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-VNRX-14079
VNRX-14079

Chemical Structure : VNRX-14079

CAS No.: 2872654-37-8

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VNRX-14079 (VNRX14079)

货号: PC-26607Not For Human Use, Lab Use Only.

VNRX-14079 is a specific Neisseria gonorrhoeae penicillin-binding protein (PBP2) inhibitor with IC50 of 1.7 uM for N. gonorrhoeae FA19 strain, exhibits potent antibacterial activity against multidrug-resistant N. gonorrhoeae through high-affinity binding to the PBP2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

VNRX-14079 is a specific Neisseria gonorrhoeae penicillin-binding protein (PBP2) inhibitor with IC50 of 1.7 uM for N. gonorrhoeae FA19 strain, exhibits potent antibacterial activity against multidrug-resistant N. gonorrhoeae through high-affinity binding to the PBP2.

物理化学性质&存储条件

分子量 646.27
分子式 C22H22BF2N4O12PS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-7-fluoro-3-((R)-2-(3-fluoro-4-phosphonophenyl)-2-(3-(methylsulfonyl)-2-oxoimidazolidine-1-carboxamido)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid

参考文献

1. Uehara T, et al. Nat Microbiol. 2026 Apr 8. doi: 10.1038/s41564-026-02309-3.

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