CAI0019 | E. faecium carbonic anhydrase inhibitor | Probechem Biochemicals

Chemical Structure : CAI0019

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CAI0019 (CAI-0019)

货号: PC-26097Not For Human Use, Lab Use Only.

CAI0019 (CAI-0019) is a potent, selective bacterial carbonic anhydrase (CA) inhibitor with Ki of 66.9 nM and 346 nM for E. faecium α-CA and E. faecium γ-CA.

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生物&药学活性

CAI0019 (CAI-0019) is a potent, selective bacterial carbonic anhydrase (CA) inhibitor with Ki of 66.9 nM and 346 nM for E. faecium α-CA and E. faecium γ-CA.
CAI0019 exhibits MICs ranging from 0.022 to 1.57 μM across the panel of 25 E. faecalis and E. faecium strains.
CAI0019 has wider range of MIC values of 0.094 to 50 μM for rarer Enterococcus strains.
CAI0019 exhibited a synergistic interaction with ampicillin and gentamicin.
CAI0019 (20 mg/kg PO, QD for 3 days) demonstrates potent antienterococcal activity in murine VRE peritonitis model after infection with E. faecium NR-31909.

物理化学性质&存储条件

分子量	318.41
分子式	C11H18N4O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-cyclohexyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)propanamide

参考文献

1. Abutaleb NS, et al. ACS Infect Dis. 2026 Jan 9;12(1):176-189.

CAI0019 (CAI-0019)

生物&药学活性

物理化学性质&存储条件

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CAI0019 (CAI-0019)

生物&药学活性

物理化学性质&存储条件

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