Mtb GuaB-IN-1

Chemical Structure : Mtb GuaB-IN-1

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货号: PC-28180Not For Human Use, Lab Use Only.

Mtb GuaB-IN-1 (Compound 15) is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB2, IMPDH) with IC50 of 1.7 nM, and MIC of0.26 uM for M.tb H37Ra.

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生物&药学活性

Mtb GuaB-IN-1 (Compound 15) is a potent, specific inhibitor of Mycobacterium tuberculosis inosine 5'-monophosphate dehydrogenase (Mtb GuaB, IMPDH) with IC50 of 1.7 nM, and MIC of0.26 uM for M.tb H37Ra.
Mtb GuaB-IN-1 is extremely selective over the human IMPDH ortholog (IC50 > 50 uM).
Mtb GuaB-IN-1 is not cytotoxic against primary human hepatocytes.
Mtb GuaB-IN-1 has a favorable ADME and safety profile.

物理化学性质&存储条件

分子量	423.86
分子式	C21H18ClN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-9-(1-(5-(3-chloro-1H-pyrazol-1-yl)pyridazin-3-yl)ethoxy)-1,2-dihydro-[1,4]oxazino[4,3-a]quinolin-6(4H)-one

参考文献

1. Zhou Y, et al. Bioorg Med Chem Lett. 2025 Mar 1;117:130026.

Mtb GuaB-IN-1

生物&药学活性

物理化学性质&存储条件

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Mtb GuaB-IN-1

生物&药学活性

物理化学性质&存储条件

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