IMP-2380 (IMP2380)

Chemical Structure : IMP-2380

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货号: PC-25364Not For Human Use, Lab Use Only.

IMP-2380 is a potent, selective small molecule inhibitor of multidrug efflux pump NorA with EC50 of 7.1 nM in SOS response assay, and IC50 of 18 nM in the potentiation of ciprofloxacin-induced bacterial growth inhibition assay.

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生物&药学活性

IMP-2380 is a potent, selective small molecule inhibitor of multidrug efflux pump NorA with EC50 of 7.1 nM in SOS response assay, and IC50 of 18 nM in the potentiation of ciprofloxacin-induced bacterial growth inhibition assay.
IMP-2380 caused a similar fold-decrease in ciprofloxacin MIC as for 1, but at ca. 10-fold lower concentration.
IMP-2380 showed no mammalian cytotoxicity and no antibacterial activity in the absence of ciprofloxacin.
IMP-2380 also potentiated ciprofloxacin activity in MRSA and MSSA clinical isolates.
IMP-2380 binds the outward-open state of NorA
IMP-2380 prevents induction of the ciprofloxacin-induced SOS response.
IMP-2380 (30 mg/kg i.p.) demonstrate robust potentiation with ciprofloxacin in murine infection model of MRSA.

物理化学性质&存储条件

分子量	409.89
分子式	C21H16ClN3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(benzo[d]thiazol-2-yl)-4-(3-(4-chlorophenyl)-1-methyl-1H-pyrazol-4-yl)but-3-enoic acid

参考文献

1. Gray JL, et al. bioRxiv [Preprint]. 2025 Aug 22:2025.08.19.671038.

IMP-2380 (IMP2380)

生物&药学活性

物理化学性质&存储条件

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IMP-2380 (IMP2380)

生物&药学活性

物理化学性质&存储条件

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