| Cat. No. |
Product Name |
Information |
| PC-27959 |
Zucapsaicin
TRPV1 agonist
|
Zucapsaicin (Civamide, (Z)-Capsaicin) is the cis isomer of Capsaicin and orally active TRPV1 agonist, has shown therapeutic efficacy in pain accompanying osteoarthritis of the knee. |
| PC-27704 |
WR1-002
TRPML1 agonist
|
WR1-002 (TRPML1 agonist C8) is a potent, selective agonist of lysosomal transient receptor potential mucolipin channel 1 (TRPML1), is >10x more potent than ML-SA1. |
| PC-27645 |
KM-001
TRPV3 inhibitor
|
KM-001 is a potent, specific TRPV3 inhibitor/antagonist, suppresses 2-APB (50 μM)-induced Ca2+ influx in HEK-293 cells transiently transfected with hTRPV3 with IC50 of 0.26 μM. |
| PC-27644 |
Colivin
TRPV3 inhibitor
|
Colivin is a potent, selective and orally bioactive TRPV3 inhibitor/antagonist, suppresses hTRPV3 activity with IC50 of 0.23 uM in Fluorescence-based Ca2+ influx assays, inhibits hTRPV3 and mTRPV3 equally. |
| PC-27337 |
TRPV1 agonist MSP20
TRPV1 agonist
|
MSP20 is a potent, selective TRPV1 agonist with EC50 of 46 nM and Emax=78.24%, shows no agonist activity against TRPV3, TRPV4 and TRPM8 receptors. |
| PC-26845 |
JD03-02
TRPC1/5 inhibitor
|
JD03-02 is a potent, highly selective small-molecule inhibitor of TRPC1/5 heteromers with IC50 of 0.2 nM, exhibiting >10,000-fold selectivity for TRPC1/5 heteromers over TRPC5 homomers. |
| PC-26577 |
BHV-2100
TRPM3 antagonist
|
BHV-2100 (Ponometrep, BHV2100) is a selective, peripherally restricted TRPM3 antagonist, inhibits human, mouse, and rat TRPM3 with IC50 of 1-10 nM, shows >1000x selectivity vs related channels and no significant off-target liabilities. |
| PC-26421 |
JD02-174A
TRPM3 antagonist
|
JD02-174A is a highly potent, specific TRPM3 antagonist with IC50 of 0.46 nM in patch-clamp assays, shows significant analgesic efficacy. |
| PC-26388 |
Isosakuranetin
TRPM3 inhibitor
|
Isosakuranetin is a flavanone natural compound and potent specific inhibitor of TRPM3 with IC50 of 50 nM. |
| PC-25774 |
Z3571
TRPC6 inhibitor
|
Z3571 is a potent, highly selective and orally bioavailable TRPC6 inhibitor with binding KD of 1.62 uM, inhibits OAG-stimulated Ca2+ influx with IC50 of 31.07 nM, shows >100-fold selectivity over TRPC3 and TRPC7. |
| PC-25470 |
TRPA1 agonist NMTA
TRPA1 agonist
|
TRPA1 agonist NMTA is a selective, nonelectrophilic transient receptor potential ankyrin 1 (TRPA1) agonist with EC50 of 50.05 uM for hTRPA1, induces Ca2+ influx and exhibits antinociceptive effects. |
| PC-24843 |
D-3263 hydrochloride
TRPM8 agonist
|
D-3263 hydrochloride is a specific small molecule agonist of transient receptor potential cation channel subfamily M member 8 (TRPM8). |
