WR1-002 (TRPML1 agonist C8)

Chemical Structure : WR1-002

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货号: PC-27704Not For Human Use, Lab Use Only.

WR1-002 (TRPML1 agonist C8) is a potent, selective agonist of lysosomal transient receptor potential mucolipin channel 1 (TRPML1), is >10x more potent than ML-SA1.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

WR1-002 (TRPML1 agonist C8) is a potent, selective agonist of lysosomal transient receptor potential mucolipin channel 1 (TRPML1), is >10x more potent than ML-SA1.

物理化学性质&存储条件

分子量	553.06
分子式	C24H26ClFN4O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-[2-[4-(4-Chloro-2-fluorophenyl)-1-piperazinyl]phenyl]-N4,N4-dimethylbenzene-1,4-disulfonamide

参考文献

1. Weiden EM, et al. EMBO J. 2026 Apr;45(7):2182-2209.

2. Patent WO2018/005713A1 (Compound 8).

3. Jonathan M Goodwin, et al. Sci Adv. 2021 Oct;7(40):eabj2485.

4. Kirsty M Hooper, et al. J Cell Biol. 2022 Jun 6;221(6):e202105112.