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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-KM-001
KM-001

Chemical Structure : KM-001

CAS No.: 2682236-50-4

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KM-001 (KM001)

货号: PC-27645Not For Human Use, Lab Use Only.

KM-001 is a potent, specific TRPV3 inhibitor/antagonist, suppresses 2-APB (50 μM)-induced Ca2+ influx in HEK-293 cells transiently transfected with hTRPV3 with IC50 of 0.26 μM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

KM-001 is a potent, specific TRPV3 inhibitor/antagonist, suppresses 2-APB (50 μM)-induced Ca2+ influx in HEK-293 cells transiently transfected with hTRPV3 with IC50 of 0.26 μM.

物理化学性质&存储条件

分子量 416.50
分子式 C26H25FN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3-(2'-cyclopropyl-3-(hydroxymethyl)-[1,1'-biphenyl]-4-yl)pyrrolidin-1-yl)(5-fluoropyridin-2-yl)methanone

参考文献

1. Wang Y, et al. EMBO J. 2026 Aug 13. doi: 10.1038/s44318-026-00896-9.

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