| Cat. No. |
Product Name |
Information |
| PC-20367 |
TRPM5 inhibitor NDNA
TRPM5 inhibitor
|
TRPM5 inhibitor NDNA is potent and selecive TRPM5 inhibitor, inhibits Ca2+- induced TRPM5 currents with IC50 of 2.4 nM. |
| PC-20366 |
Triphenylphosphine oxide
TRPM5 inhibitor
|
Triphenylphosphine oxide (TPPO) is a selective and potent inhibitor of TRPM5 with IC50 of 12 and 30 uM for human and murine TRPM5 heterologously expressed in HEK293 cells. |
| PC-49702 |
AZ465
TRPA1 inhibitor
|
AZ465 (AZ-465) is a potent selective TRPA1 inhibitor, potently inhibitor Zn2+ (100 μM)- and O-chlorobenzylidene malononitrile (CS) (10 nM)-induced TRPA1 activation with IC50 of 85 nM and 20 nM, respectively. |
| PC-49701 |
AMG2504
TRPA1 inhibitor
|
AMG2504 (AMG 2504) is a selective small molecule TRPA1 inhibitor, inhibits AITC-induced increase in intracellular calcium mediated by TRPA1 in CHO cells with IC50 of 35 nM. |
| PC-49700 |
GRC-17536
TRPA1 inhibitor
|
GRC-17536 (GRC 17536) is a potent and selective TRPA1 antagonist, inhibits citric acid -induced Ca+2 influx with IC50 of 8.2 nM in cell-based assays. |
| PC-49696 |
BAY-390
TRPA1 inhibitor
|
BAY-390 (BAY390) is a potent, selective, brain-penetrant TRPA1 inhibitor with IC50 of 16 and 63 nM for hTRPA1 and rTRPV1, respectively. |
| PC-49684 |
JT010
TRPA1 agonist
|
JT010 (JT-010) is a potent, site-selective and covalent TRPA1 agonist, opens the TRPA1 channel by covalently and site-selectively binding to Cys621 with EC50 of 0.65 nM. |
| PC-49536 |
TRPM5 agonist 39
TRPM5 agonist
|
TRPM5 agonist 39 is a potent, selective transient receptor potential cation channel subfamily M member 5 (TRPM5) agonist with pEC50 of 7.1, shows high selectivity over TRPA1, TRPV1, TRPV4, TRPM4 and TRPM8. |
| PC-49443 |
AMG21629
TRPV1 antagonist
|
AMG21629 is a potent and selective TRPV1 antagonist, inhibits Ca2+ uptake by CHO cells expressing TRPV1 receptors with IC50 of 0.6 nM and 0.8 nM for capsaicin and acid-induced Ca2+ uptake, respectively. |
| PC-49411 |
Trpvicin
TRPV3 inhibitor
|
Trpvicin is a potent and subtype-selective inhibitor of TRPV3 with IC50 of 0.41 and 0.22 uM for hTRPV3-WT and hTRPV3-G573S mutant, respectively. |
| PC-49275 |
KS0365
TRPV3 activator
|
KS0365 (KS 0365) is a potent and selective activator of transient receptor potential vanilloid 3 (TRPV3) channel with EC50 of 5.08 uM. |
| PC-47023 |
JNc-463
TRPV4-eNOS activator
|
JNc-463 is a small-molecule that could increase the TRPV4-eNOS interaction, enhances vasodilation and exert antihypertensive effects in mice. |
