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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-TRPM2 inhibitor D10
TRPM2 inhibitor D10

Chemical Structure : TRPM2 inhibitor D10

CAS No.: 2833727-43-6

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TRPM2 inhibitor D10

货号: PC-25551Not For Human Use, Lab Use Only.

TRPM2 inhibitor D10 is a highly seletive small molecule TRPM2 inhibitor with IC50 of 2.29 uM, demonstrates significant neuroprotective effects in vitro, shows robust efficacy in reducing cerebral infarction in a transient middle cerebral artery occlusion (tMCAO) model.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

TRPM2 inhibitor D10 is a highly seletive small molecule TRPM2 inhibitor with IC50 of 2.29 uM, demonstrates significant neuroprotective effects in vitro, shows robust efficacy in reducing cerebral infarction in a transient middle cerebral artery occlusion (tMCAO) model.

物理化学性质&存储条件

分子量 320.39
分子式 C20H20N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-Benzoyl-N,N-diethyl-7-indolizinecarboxamide

参考文献

1. Lu T, et al. J Med Chem. 2025 Apr 10;68(7):7642-7661.

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