Isosakuranetin

Chemical Structure : Isosakuranetin

CAS No.: 480-43-3

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货号: PC-26388Not For Human Use, Lab Use Only.

Isosakuranetin is a flavanone natural compound and potent specific inhibitor of TRPM3 with IC50 of 50 nM.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Isosakuranetin is a flavanone natural compound and potent specific inhibitor of TRPM3 with IC50 of 50 nM.
Isosakuranetin exhibits a marked specificity for TRPM3 compared with other sensory TRP channels.
Isosakuranetin blocked PregS-induced intracellular free Ca²⁺ concentration signals and ionic currents in freshly isolated DRG neurons.
Isosakuranetin significantly reduced the sensitivity of mice to noxious heat and PregS-induced chemical pain.
Isosakuranetin dose-dependently alleviated mechanical, thermal, and cold hyperalgesia in rat model of peripheral neuropathy.

物理化学性质&存储条件

分子量	286.28
分子式	C16H14O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-5,7-Dihydroxy-2-(4-methoxyphenyl)chroman-4-one

参考文献

1. Vangeel L, et al. Br J Pharmacol. 2020 Jun;177(12):2683-2695.

2. Straub I, et al. Mol Pharmacol. 2013 Nov;84(5):736-50.

Isosakuranetin

生物&药学活性

物理化学性质&存储条件

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Isosakuranetin

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物理化学性质&存储条件

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