Z3571 | TRPC6 inhibitor | Probechem Biochemicals

Chemical Structure : Z3571

加入收藏

Z3571 (Z-3571)

货号: PC-25774Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Z3571 is a potent, highly selective and orally bioavailable TRPC6 inhibitor with binding KD of 1.62 uM, inhibits OAG-stimulated Ca2+ influx with IC50 of 31.07 nM, shows >100-fold selectivity over TRPC3 and TRPC7.
Z3571 (1 uM) specifically inhibits TRPC6-mediated Ca2+ signaling, attenuates the OAG-induced [Ca2+]i elevation in murine podocyte clone cell line MPC-5 cells, with no significant suppression of Tg- or EA-induced [Ca2+]i elevation, suggesting no detectable activity against TRPC1/4/5 channels.
Z3571 attenuates ADR-induced injury in MPC-5 cells by targeting TRPC6.
Z3571 concentration-dependently suppresses the expression and channel function of TRPC6 in ADR-injured podocytes.
Z3571 suppresses TGF-β1-induced fibrosis in HK-2 cells by targeting TRPC6
Z3571 (12.5/25/50 mg/kg) dose-dependently restores kidney function and reduces podocyte damage in FSGS model mice.
Z3571 significantly ameliorates kidney function and reduces renal fibrosis in mice with UUO.

物理化学性质&存储条件

分子量	246.27
分子式	C13H14N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[(1-methyl-1H-indole-2-carbonyl) amino] propionic acid

参考文献

1. Lei Zhou, et al. Biochem Pharmacol. 2025 Nov 21:117557.

Z3571 (Z-3571)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Z3571 (Z-3571)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.