TRPM8 inhibitor PBMC

Chemical Structure : TRPM8 inhibitor PBMC

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货号: PC-25977Not For Human Use, Lab Use Only.

PBMC is a highly specific and potent TRPM8 antagonist with IC50 of 0.4-0.6 nM in whole-cell voltage clamp assays.

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生物&药学活性

PBMC is a highly specific and potent TRPM8 antagonist with IC50 of 0.4-0.6 nM in whole-cell voltage clamp assays.
PBMC shows selective inhibition of heterologously expressed TRPM8 over TRPV1 and TRPA1.
PBMC shifts the voltage-dependence of TRPM8 channels.
PBMC affects body temperature in a dose-dependent manner in mice.
PBMC reduces acute cold-evoked behavioral responses. PBMC reduces cold hypersensitivity in CFA and CCI but not oxaliplatin pain models.

物理化学性质&存储条件

分子量	434.54
分子式	C26H30N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-phenylethyl-4-(benzyloxy)-3-methoxybenzyl(2-aminoethyl)carbamate

参考文献

1. Knowlton WM, et al. PLoS One. 2011;6(9):e25894.

2. Gardiner JC, et al. Eur J Pharmacol. 2014 Oct 5;740:398-409.