| Cat. No. |
Product Name |
Information |
| PC-35928 |
GSK1702934A
TRPC3/6 activator
|
GSK1702934A (GSK-1702934A) is a potent and selective TRPC3/6 activator with EC50 of 80/440 nM, respectively. |
| PC-35713 |
GSK3395879
TRPV4 inhibitor
|
GSK3395879 (GSK-3395879) is a novel potent, selective, orally bioavailable antagonist of TRPV4 with IC50 of 1 nM (hTRPV4). |
| PC-35612 |
AMG333
TRPM8 antagonist
|
AMG333 (AMG-333) is a potent, highly selective TRPM8 antagonist with IC50 of 13 nM and 20 nM for hTRPM8 and rTRPM8, respectively. |
| PC-35474 |
TRPM8 antagonist 14
TRPM8 antagonist
|
TRPM8 antagonist 14 is a potent, selective TRPM8 antagonist with IC50 of 0.2 nM in calcium influx assays, shows no activity on TRPV1. |
| PC-35235 |
AS1928370
TRPV1 inhibitor
|
AS1928370 (ASP8370) is a potent, selective, orally available TRPV1 antagonist with IC50 of 0.51 uM, shows no inhibitory effects on TRPV4, TRPA11, and TRPM8 at 10 uM. |
| PC-35234 |
TRPM4 inhibitor 5
TRPM4 inhibitor, TMEM206 inhibitor
|
TRPM4 inhibitor 5 (TMEM206 inhibitor CBA) is a potent and selective inhibitor of TRPM4 with IC50 of 1.5 uM (Na+ influx), also inhibits TMEM206 with IC50 of 9.55 uM. |
| PC-35045 |
DS88790512 hydrochloride
TRPC6 inhibitor
|
DS88790512 is a potent, selective, and orally bioavailable TRPC6 blocker with IC50 of 11 nM, exhibits excellent selectivity against hERG and hNaV1.5 channels (IC50 >100 uM). |
| PC-35044 |
DS88790512
TRPC6 inhibitor
|
DS88790512 is a potent, selective, and orally bioavailable TRPC6 blocker with IC50 of 11 nM, exhibits excellent selectivity against hERG and hNaV1.5 channels (IC50 >100 uM). |
| PC-63429 |
JNJ-38893777 sulfate
TRPV1 antagonist
|
JNJ-38893777 sulfate is a potent and selective transient receptor potential vanilloid 1 (TRPV1) channel antagonist for treatment of ociceptive and neuropathic pain. |
| PC-63428 |
JNJ-38893777
TRPV1 inhibitor
|
JNJ-38893777 is a potent and selective transient receptor potential vanilloid 1 (TRPV1) channel antagonist for treatment of ociceptive and neuropathic pain. |
| PC-63414 |
JNJ-39729209
TRPV1 antagonist
|
JNJ-39729209 is a potent, selective TRPV1 antagonist with binding pKi of 7.8 and 7.9 for human and rat TRPV1, respectively. |
| PC-43289 |
ML204 hydrochloride
TRPC4/TRPC5 inhibitor
|
ML204 hydrochloride is a potent, selective antagonist of TRPC4 and TRPC5 channels, inhibits TRPC4β-mediated intracellular Ca(2+) rise with IC50 of 0.96 uM, exhibits 19-fold selectivity against TRPC6 channel. |
