| Cat. No. |
Product Name |
Information |
| PC-72922 |
JW-65
TRPC3 inhibitor
|
JW-65 (JW65) is a selective, potent, CNS-permeable TRPC3 inhibitor improved stability compared to Pyr3. |
| PC-72671 |
ML2-SA1
TRPML2 agonist
|
ML2-SA1 is a potent, selective and efficacious activator (agonist) of TRPML2 with EC50 of 1.24 uM and 2.38 uM for human and mouse TRPML2, respectively. |
| PC-72599 |
GSK2798745
TRPV4 inhibitor
|
GSK2798745 (GSK-2798745) is a potent, selective TRPV4 inhibitor with IC50 of 1.8/1.6 nM (hTRPV4/rTRPV4). |
| PC-72566 |
SH045
TRPC6 inhibitor
|
SH045 (SH-045, Larixyl-6-N-methylcarbamate) is a potent, selective TRPC6 antagonist (blocker) with IC50 of 63 nM. |
| PC-72565 |
BI-749327
TRPC6 inhibitor
|
BI-749327 (BI 749327) is a potent, selective orally bioavailable TRPC6 antagonist (blocker) with IC50 of 13/19/15 nM for mouse/human/guinea pig TRPC6, respectively. |
| PC-72460 |
GDC-0334
TRPA1 antagonist
|
GDC-0334 (GDC0334) is a highly potent, selective, orally bioavailable TRPA1 antagonist with IC50 of 1.7 nM in cell-based assays. |
| PC-72354 |
RGM8-51
TRPM8 antagonist
|
RGM8-51 is a β-lactam derivative, potent, selective TRPM8 antagonist with IC50 of 1.06 and 1.74 uM for rat and human TRPM8, respectively. |
| PC-72125 |
JNJ-28583113
TRPM2 antagonist
|
JNJ-28583113 (JNJ28583113) is a potent, selective, brain penetrant TRPM2 antagonist with IC50 of 126 nM (hTRPM2). |
| PC-72123 |
AM237
TRPC5 activator
|
AM237 is a selective TRPC5 channel activator that potently activated homomeric TRPC5:C5 channels (EC50=15–20 nM in Ca2+i assays). |
| PC-72122 |
tatM2NX
TRPM2 antagonist
|
tatM2NX is a novel potent, selective, cell permeable, peptide TRPM2 channel antagonist with IC50 of 396 nM, IC90 of 2 uM (TRPM2 channel currents), prevents ligand binding and TRPM2 activation. |
| PC-72111 |
KPR-5714
TRPM8 antagonist
|
KPR-5714 (KPR5714) is a novel potent, selective TRPM8 antagonist with IC50 of 25.3 and 22.4 nM against hTRPM8 and rTRPM8, respectively. |
| PC-72043 |
ML-SA5
TRPML1 agonist
|
ML-SA5 (TRPML1 agonist ML-SA5) is a potent, small molecule agonist of transient receptor potential mucolipin 1 (TRPML1/MCOLN1/ML1), dose-dependently activated whole-endolysosomal ML1 currents in DMD myoblasts with EC50 of 285±144 nM. |
