Motugivatrep (SJP-0132) | TRPV1 antagonist | Probechem Biochemicals

Chemical Structure : Motugivatrep

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Motugivatrep (SJP-0132, SJP0132)

货号: PC-73430Not For Human Use, Lab Use Only.

Motugivatrep (SJP-0132) is a potent, selective transient receptor potential vanilloid 1 (TRPV1) antagonist, inhibits capsaicin-stimulated TRPV1 across multiple species with IC50 of 0.46-2.1 nM.

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生物&药学活性

Motugivatrep (SJP-0132) is a potent, selective transient receptor potential vanilloid 1 (TRPV1) antagonist, inhibits capsaicin-stimulated TRPV1 across multiple species with IC50 of 0.46-2.1 nM.

Motugivatrep exhibits weak inhibition of human TRPV4, and has no significant effects on TRPV3, TRPA1, or TRPM8.

Motugivatrep also shows minimal binding to 5-HT2A and 5-HT2B receptors.

Motugivatrep suppresses capsaicin-induced intracellular Ca2+ influx in DRG cells with IC50 of 2.8 nM.

Motugivatrep shows potential for disorders associated with TRPV1 activation, such as dry eye disease (DED).

物理化学性质&存储条件

分子量	403.401
分子式	C22H20F3NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R,E)-N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-2-(7-(trifluoromethyl)chroman-4-ylidene)acetamide

参考文献

1. Hori Y, et al. Am J Ophthalmol. 2026 Mar;283:163-175. 2. Uemura T, et al. Biol Pharm Bull. 2026;49(9):1524-1528.

Motugivatrep (SJP-0132, SJP0132)

生物&药学活性

物理化学性质&存储条件

参考文献

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Motugivatrep (SJP-0132, SJP0132)

生物&药学活性

物理化学性质&存储条件

参考文献

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