TRPA1 agonist NMTA | TRPA1 agonist | Probechem Biochemicals

Chemical Structure : TRPA1 agonist NMTA

CAS No.: 3083086-77-2

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TRPA1 agonist NMTA (TRPA1 agonist-3)

货号: PC-25470Not For Human Use, Lab Use Only.

TRPA1 agonist NMTA is a selective, nonelectrophilic transient receptor potential ankyrin 1 (TRPA1) agonist with EC50 of 50.05 uM for hTRPA1, induces Ca2+ influx and exhibits antinociceptive effects.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

TRPA1 agonist NMTA is a selective, nonelectrophilic transient receptor potential ankyrin 1 (TRPA1) agonist with EC50 of 50.05 uM for hTRPA1, induces Ca2+ influx and exhibits antinociceptive effects.
NMTA does not activate hTRPV1, mTRPV2, hTRPV3, hTRPV4, hTRPC6 and hTRPM8 channels individually expressed in HEK-293T cells.
NMTA (10-3000 μM) could activate mTRPA1 channels in a concentration-dependent manner (EC50=314.04 uM), activated and desensitized mTRPA1 channels.
NMTA (10, 20, and 40 mg/kg, oral) demonstrates antinociceptive effects on CFA-induced inflammatory pain in mice.

物理化学性质&存储条件

分子量	262.37
分子式	C14H18N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-methoxypropyl)-4-(p-tolyl)thiazol-2-amine

参考文献

1. Sun C, et al. ACS Chem Neurosci. 2025 Sep 3;16(17):3257-3266.

TRPA1 agonist NMTA (TRPA1 agonist-3)

生物&药学活性

物理化学性质&存储条件

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TRPA1 agonist NMTA (TRPA1 agonist-3)

生物&药学活性

物理化学性质&存储条件

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