| Cat. No. |
Product Name |
Information |
| PC-28250 |
PDE3 inhibitor K-134
PDE3 inhibitor
|
K-134 (OPC-33509) is a potent, selective phosphodiesterase-3 (PDE3) inhibitor with IC50 of 0.1 uM and 0.28 uM for PDE3A and PDE3B, shows much weaker activity for PDE5 and does not inhibit PDE2 and PDE4. |
| PC-28174 |
Ro 20-1724
PDE4 inhibitor
|
Ro 20-1724 (Ro20-174) is a potent, selective inhibitor of phosphodiesterase 4 (PDE4) with Ki of 1.93 uM, shows neuroprotective effects. |
| PC-28125 |
L-869298
PDE4 inhibitor
|
L-869298 (L-869,298) is a potent, selective and orally active PDE4 inhibitor with IC50 of 0.5 nM for PDE4A, shows less active against hERG. |
| PC-28124 |
Theophylline
PDE inhibitor
|
Theophylline (1,3-Dimethylxanthine) is a non-selective oral phosphodiesterase (PDE) inhibitor, is also a adenosine receptor antagonist and histone deacetylase (HDAC) activator, inhibits PDE3 activity to relax airway smooth muscle, also has anti-inflammatory activity by increase IL-10 and inhibits NF-κB, induces apoptosis. |
| PC-28123 |
MK-0873
PDE4 inhibitor
|
MK-0873 is a potent and orally active phosphodiesterase 4 (PDE4) inhibitor with IC50 of 6.7 nM (PDE4A), inhibits LPS-induced TNF-α production in human whole blood with IC50 of 178 nM. |
| PC-27885 |
YS3375
ENPP1 inhibitor
|
YS3375 is a potent and selective ENPP1 inhibitor with IC50 of 19.4 nM, shows weak to negligible ENPP2 and ENPP3 inhibition. |
| PC-27884 |
YS2219
ENPP1 inhibitor
|
YS2219 is a highly potent and selective ENPP1 inhibitor with IC50 of 5.70 or 9.68 nM, shows weak inhibition against ENPP2 and ENPP3 (IC50>2500 nM). |
| PC-27883 |
YS3074
ENPP1 inhibitor
|
YS3074 is a potent and selective ENPP1 inhibitor with IC50 of 4.23 nM, shows weak to negligible ENPP2 and ENPP23 inhibition. |
| PC-27748 |
LW1646
PDE5 inhibitor
|
LW1646 is a potent, selective and orally available PDE5 inhibitor with IC50 of 1.09 nM, exerts antifibrotic effects. |
| PC-27123 |
PDE11A4 inhibitor 15c
PDE11A4 inhibitor
|
PDE11A4 inhibitor 15c is a potent, selective PDE11A4 inhibitor with IC50 of 33 nM. |
| PC-26398 |
MT-3014
PDE10A inhibitor
|
MT-3014 is a potent, highly selective PDE10A inhibitor with IC50 of 0.062 nM and 0.090 nM for human and bovine PDE10A, >1000-fold selective over other PDEs. |
| PC-26351 |
Prifemilast
PDE4 inhibitor
|
Prifemilast (HPP737) is a potent, selective, oral phosphodiesterase-4 (PDE4) inhibitor. |
