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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-Theophylline
Theophylline

Chemical Structure : Theophylline

CAS No.: 58-55-9

Theophylline (1,3-Dimethylxanthine)

货号: PC-28124Not For Human Use, Lab Use Only.

Theophylline (1,3-Dimethylxanthine) is a non-selective oral phosphodiesterase (PDE) inhibitor, is also a adenosine receptor antagonist and histone deacetylase (HDAC) activator, inhibits PDE3 activity to relax airway smooth muscle, also has anti-inflammatory activity by increase IL-10 and inhibits NF-κB, induces apoptosis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Theophylline (1,3-Dimethylxanthine) is a non-selective oral phosphodiesterase (PDE) inhibitor, is also a adenosine receptor antagonist and histone deacetylase (HDAC) activator, inhibits PDE3 activity to relax airway smooth muscle, also has anti-inflammatory activity by increase IL-10 and inhibits NF-κB, induces apoptosis.

物理化学性质&存储条件

分子量 180.17
分子式 C7H8N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,3-Dimethyl-1H-purine-2,6(3H,9H)-dione

参考文献

1. Katz S, et al. Br J Pharmacol. 1973 Jul;48(3):505-15.

2. Uzunov P, et al. Acta Neurobiol Exp (Wars). 1975;35(2):159-64.

3. Haliotis T, et al. J Natl Cancer Inst. 1984 May;72(5):991-8.

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