| Cat. No. |
Product Name |
Information |
| PC-61617 |
GSK256066
PDE4 inhibitor
|
GSK256066 is a highly potent, selective PDE4B inhibitor with pIC50 of 11.1, apparent IC50 of 3.2 pM, inhibits PDE4 isoforms A-D with equal affinity. |
| PC-61387 |
Lotamilast
PDE4 inhibitor
|
Lotamilast (RVT 501, E6005) is a potent, selective PDE4 inhibitor with IC50 of 2.8 nM, suppresses the production of various cytokines from human lymphocytes and monocytes with IC50 of 0.49-3.1 nM. |
| PC-61372 |
Difamilast
PDE4B inhibitor
|
Difamilast (OPA-15406) is a novel potent, selective phosphodiesterase IV (PDE4) inhibitor with preference for PDE4B (IC50=11.2 nM). |
| PC-61348 |
PQ-10
PDE10A inhibitor
|
PQ-10 is a potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM. |
| PC-61347 |
TC-E 5005
PDE10A inhibitor
|
TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 of 7.28 nM. |
| PC-61346 |
BMS-843496
PDE10A inhibitor
|
BMS-843496 is a potent and selective PDE10A inhibitor with binding affinity (Kd) of 0.15 nM, IC50 of 2.11 nM. |
| PC-61345 |
ADT-094
PDE5/PDE10 inhibitor
|
ADT-094 (ADT094) is a novel, non-COX inhibitory sulindac derivative that potently and selectivity inhibits colon tumor cell growth by inhibiting PDE5 and PDE10 with IC50 of 2.4 uM and 0.5 uM, respectively. |
| PC-61344 |
MY-5445
PDE5 inhibitor
|
MY-5445 is a specific PDE5 inhibitor that inhibits human platelet aggregation induced by 3 uM ADP, 3 mg/ml of collagen and 100 ug/ml of arachidonic acid with IC50 of 0.07, 0.02 and 0.17 uM, respectively. |
| PC-61343 |
Lu AF-58027
PDE1 inhibitor
|
Lu AF-58027 is a potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively. |
| PC-61342 |
PF-04471141 hydrochloride
PDE1 inhibitor
|
PF-04471141 hydrochloride is a potent and selective, CNS-penetrant PDE1 inhibitor with IC50 of 35 nM for PDE1B. |
| PC-61341 |
PF-04822163
PDE1 inhibitor
|
PF-04822163 is a potent and selective, CNS-penetrant PDE1 inhibitor with IC50 of 2.4 nM for PDE1B. |
| PC-61339 |
BRL-50481
PDE7 inhibitor
|
BRL-50481 (BRL50481) is a potent and selective, competitive PDE7 inhibitor with Ki of 180 nM, displays >200-fold selectivity over PDE1B/1C/2/3/4A/5. |
