| Cat. No. |
Product Name |
Information |
| PC-35833 |
PF-04449613
PDE9 inhibitor
|
PF-04449613 (PF-9613, PF04449613, PF 04449613) is a potent and selective inhibitor of PDE9 with IC50 of 22 nM, >50-fold selective over PDE1C (IC50>1000 nM). |
| PC-43473 |
Vinpocetine
PDE1 inhibitor
|
Vinpocetine (Ethyl apovincaminate) is a synthetic derivative of the vinca alkaloid vincamine, selectively inhibits PDE1 in isolated rabbit aorta with IC50 of 21 uM. |
| PC-63527 |
PF-04827736
PDE1 inhibitor
|
PF-04827736 ((S)-PF-04677490) is a potent, selective PDE1 inhibitor with IC50 of 42, 9.1 and 38 nM for PDE1A, PDE1B and PDE1C, respectively. |
| PC-63526 |
PF-04677490
PDE1 inhibitor
|
PF-04677490 is a potent, selective PDE1 inhibitor with IC50 of 21 nM for PDE1B. |
| PC-63331 |
MPPA
sEH/PDE4 inhibitor
|
MPPA is a potent, orally bioavailable sEH/PDE4 dual inhibitor with IC50 of 2.1 nM and 8.1 nM for hsEH and PDE4, respectively. |
| PC-63306 |
PDE10A-IN-32
PDE10A inhibitor
|
PDE10A-IN-32 is a potent, highly selective, brain penetrant PDE10A inhibitor with IC50 of 0.14 nM, displays no significant activity against other PDEs (IC50>1,000 nM). |
| PC-43068 |
ITI-214
PDE1 inhibitor
|
ITI-214 (Lenrispodun) is a potent, selective, orally active phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms. |
| PC-43067 |
ITI214 free base
PDE1 inhibitor
|
ITI-214 is a potent, selective phosphodiesterase 1 (PDE1) inhibitor with Ki of 58 pM, displays >1,000-fold selectivity over PDE4A/4D and other PDE isoforms. |
| PC-43051 |
TAK-063
PDE10A inhibitor
|
TAK-063 (Balipodect) is a highly potent, selective, orally active PDE10A inhibitor with IC50 of 0.3 nM, displays >15,000-fold selectivity over other PDE subtypes. |
| PC-42971 |
IBMX
PDEs inhibitor
|
IBMX (Isobutylmethylxanthine, Methylisobutylxanthine, NSC165960) is a broad-spectrum inhibitor of cyclic AMP and cyclic GMP phosphodiesterases (PDEs) with IC50 of 5-50 uM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11. |
| PC-42891 |
Apremilast
PDE4 inhibitor
|
Apremilast (CC-10004) is a potent, orally active PDE4 inhibitor with IC50 of 74 nM, inhibits TNF-α production in LPS-stimulated hPBMCs with IC50 of 77 nM. |
| PC-63121 |
PDE4D-IN-26b
PDE4D inhibitor
|
PDE4D-IN-26b is a potent, highly selective PDE4D inhibitor with IC50 of 0.6 nM, displays 75-fold lower activity against the PDE4A, B, and C subtypes, also exhibits 18,000-fold decreased potency against other PDE family members. |
