STF-1623 (ENPP1 inhibitor 32)

Chemical Structure : STF-1623

CAS No.: 2298391-60-1

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货号: PC-38280Not For Human Use, Lab Use Only.

STF-1623 (ENPP1 inhibitor 32) is a potent, cell-impermeable small molecule inhibitor of ENPP1 with Ki of < 2 nM, IC50 of 0.6 and 0.4 nM for human and mouse ENPP1 respectively.

规格	价格	库存
2 mg	￥1980	In stock
5 mg	￥3280	In stock
10 mg	￥5280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

STF-1623 (ENPP1 inhibitor 32) is a potent, cell-impermeable small molecule inhibitor of ENPP1 with Ki of < 2 nM, IC50 of 0.6 and 0.4 nM for human and mouse ENPP1 respectively.
ENPP1 inhibitor 32 prevents cGAMP degradation in mouse and human plasma at nanomolar concentrations (IC95=40 nM).
ENPP1 inhibitor 32 exhibits excellent physicochemical and pharmacokinetic properties, and delays tumor growth in a breast cancer mouse model.

物理化学性质&存储条件

分子量	351.343
分子式	C16H22N3O4P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO (3.5 mg/mL)
Chemical Name/SMILES	P-[2-[1-(8-Methoxy-4-quinazolinyl)-4-piperidinyl]ethyl]phosphonic acid

参考文献

1. Jacqueline A Carozza, et al. Cell Chem Biol. 2020 Nov 19;27(11):1347-1358.e5.
2. Johnson RM, et al. bioRxiv [Preprint]. 2025 May 22:2025.05.18.654655.