| Cat. No. |
Product Name |
Information |
| PC-21517 |
PDE4B inhibitor A-33
PDE4B inhibitor
|
PDE4B inhibitor A-33 is a potent, selective inhibitor of PDE4B with IC50 of 15 nM, >100-fold selective over PDE4D. |
| PC-21464 |
ME3183
PDE4 inhibitor
|
Morcamilast (ME3183) is a potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 2.33, 1.28 and 1.63 nM for PDE4B1, PDE4A1A and PDE4D2 respectively. |
| PC-21326 |
ENPP1 inhibitor 29f
ENPP1 inhibitor
|
ENPP1 inhibitor 29f is a potent, orally active inhibitor of ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), inhibits the cGAMP hydrolysis by ENPP1 in vitro with IC50 of 68 nM. |
| PC-21325 |
MV-658
ENPP1 inhibitor
|
MV658 (ENPP-1-IN-1) is a potent small molecule ENPP1 inhibitor (IC50= 11 nM) as immune modulator.r. |
| PC-21270 |
SMQ-02-57
PDE11A4 inhibitor
|
SMQ-02-57 (PDE11A4 inhibitor 23b) is a potent, selective PDE11A4 inhibitor with IC50 of 12 nM. |
| PC-20916 |
Sildenafil
PDE5 inhibitor
|
Sildenafil (UK-92480) is a potent, selective, orally active phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 3.9 nM. |
| PC-20682 |
PF-07038124
PDE4B2 inhibitor
|
Idrebormilast (PF-07038124) is a highly potent, selective PDE4 inhibitor with IC50 of 0.5 nM for PDE4B2 in SPA assays. |
| PC-20681 |
Roflumilast
PDE4 inhibitor
|
Roflumilast (APTA-2217) is a potent, selective, orally active PDE4 inhibitor with IC50 of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively. |
| PC-20471 |
PDE4 inhibitor Compound A
PDE4B2 inhibitor
|
PDE4 inhibitor Compound A is a potent, highly selective PDE4 inhibitor with IC50 of 1.1 nM (PDE4B2), weakly inhibits PDE3 (IC50=150 nM) and does not inhibit other PDE subtypes. |
| PC-20038 |
Gemlapodect
PDE10A inhibitor
|
Gemlapodect (NOE-105) is a potent, selective PDE10A inhibitor with a potential therapeutic effect for the treatment of COFD. |
| PC-49676 |
Nerandomilast
PDE4B inhibitor
|
Nerandomilast (BI 1015550, VRN024219) is a potent, selective PDE4B inhibitor that preferentially inhibits hydrolysis of cAMP by PDE4B with IC50 of 10 nM, weakly inhibits PDE4A/4C/4D (IC50=248/8700/91 nM, respectively). |
| PC-49587 |
Orismilast
PDE4 inhibitor
|
Orismilast (LEO-32731) is a potent, selective, second generation PDE4 inhibitor with IC50 values of 3-52 nM for PDE4A/4B/4D subtype splice variants. |
