| Cat. No. |
Product Name |
Information |
| PC-49573 |
CRD733
PDE9A inhibitor
|
CRD733 (ASP4901) is a potent, selective cGMP-specific PDE9 (phosphodiesterase 9) inhibitor. |
| PC-49572 |
BAY-7081
PDE9A inhibitor
|
BAY-7801 (BAY7801) is a potent, selective, and orally bioavailable PDE9A inhibitor with IC50 of 15 nM (human PDE9A), 49-fold selectivity over PDE1. |
| PC-49494 |
MK-8189
PDE10A inhibitor
|
MK-8189 (Elpipodect, MK8189) is a highly potent, selective PDE10A inhibitor with Ki of 29 pM, 500,000-fold selectivity over the other PDE enzyme families (PDE1-PDE11). |
| PC-49420 |
MCI-030
PDE10 inhibitor
|
MCI-030 (ADT 061) is a potent, selective PDE10 inhibitor, inhibits recombinant PDE10 using cGMP as a substrate with IC50 of 0.3 uM. |
| PC-49288 |
TPN171
PDE5 inhibitor
|
Simenafil (TPN171, TPN-171) is a highly potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 0.62 nM, 32-fold selectivity over PDE6. |
| PC-47111 |
DSR-141562
PDE1 inhibitor
|
DSR-141562 (DSR141562) is a potent, selective orally available and brain-penetrant phosphodiesterase 1 (PDE1) inhibitor with IC50 of 97.6, 43.9 and 431.8 nM for human PDE1A, PDE1B and PDE1C, respectively. |
| PC-47068 |
TOP-N53
PDE5 inhibitor
|
TOP-N53 is a dual-acting nitric oxide (NO) donor and selective PDE5 inhibitor, potently inhibits PDE5 with IC50 of 1.6 nM. |
| PC-38810 |
Yonkenafil
PDE5 inhibitor
|
Yonkenafil (Tunodafil) is a potent, selective PDE5 inhibitor with IC50 of 2.0 nM. |
| PC-38701 |
PF-04957325
PDE8 inhibitor
|
PF-04957325 is a highly potent and selective PDE8 inhibitor with IC50 values of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively. |
| PC-38401 |
Irsenontrine
PDE9 inhibitor
|
Irsenontrine (E2027) is a potent, selective and orally active phosphodiesterase 9 (PDE9) inhibitor, reduces the degradation of cyclic GMP (cGMP) which is critical to signal transmission among cells, and helps maintain the concentration of cGMP in the brain. |
| PC-73431 |
Mufemilast
PDE4 inhibitor
|
Mufemilast (Hemay005) is a potent, selective, first-in-class PDE4 inhibitor with in vitro IC50 of 80-120 nM, exhibits comparable inhibitory activities to apremilast. |
| PC-73314 |
BAY2666605
PDE3A-SLFN12 inducer
|
BAY2666605 (BAY 2666605) is a potent, small molecule PDE3A-SLFN12 complex inducer with EC50 of 7 nM. |
