Trequinsin hydrochloride (HL 725)

Chemical Structure : Trequinsin hydrochloride

CAS No.: 78416-81-6

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货号: PC-62884Not For Human Use, Lab Use Only.

Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PDE3 IC50=250 pM), inhibits arachidonic acid-induced aggregation of human platelets with IC50 of 50 pM.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PDE3 IC50=250 pM), inhibits arachidonic acid-induced aggregation of human platelets with IC50 of 50 pM.
Trequinsin reduces systemic blood pressure in both normotensive and hypertensive animal models.

物理化学性质&存储条件

分子量	441.956
分子式	C24H28ClN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride

参考文献

1. Lal B, et al. J Med Chem. 1984 Nov;27(11):1470-80.

2. Ruppert D, et al. Life Sci. 1982 Nov 8;31(19):2037-43.

3. Darius H, et al. Br J Pharmacol. 1985 Mar;84(3):735-41.

4. Blaskó G, et al. Thromb Res. 1986 Jul 15;43(2):249-50.