PDE3 inhibitor K-134 (OPC-33509) | PDE3 inhibitor | Probechem Biochemicals

Chemical Structure : PDE3 inhibitor K-134

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PDE3 inhibitor K-134 (OPC-33509, OPC33509, K134)

货号: PC-28250Not For Human Use, Lab Use Only.

K-134 (OPC-33509) is a potent, selective phosphodiesterase-3 (PDE3) inhibitor with IC50 of 0.1 uM and 0.28 uM for PDE3A and PDE3B, shows much weaker activity for PDE5 and does not inhibit PDE2 and PDE4.

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100 mg		Get quote

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生物&药学活性

K-134 (OPC-33509) is a potent, selective phosphodiesterase-3 (PDE3) inhibitor with IC50 of 0.1 uM and 0.28 uM for PDE3A and PDE3B, shows much weaker activity for PDE5 and does not inhibit PDE2 and PDE4.
K-134 also inhibits binding between CD36 and collagen type-I.
K-134 blocks rat platelet aggregation more potently than cilostazol in vitro.
K-134 inhibits mouse platelet aggregation induced by collagen and ADP in a dose-dependent manner.

物理化学性质&存储条件

分子量	399.49
分子式	C22H29N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-cyclopropyl-1-((1R,2R)-2-hydroxycyclohexyl)-3-(3-((2-oxo-1,2-dihydroquinolin-6-yl)oxy)propyl)urea

参考文献

1. Yoshida H, et al. PLoS One. 2012;7(10):e46432.

2. Sasaki Y, et al. Eur J Pharmacol. 2012 Aug 15;689(1-3):132-8.

3. Ikenoya M, et al. Biochem Biophys Res Commun. 2007 Feb 23;353(4):1111-4.

4. Sudo T, et al. Biochem Pharmacol 2000, 59: 347–356.

PDE3 inhibitor K-134 (OPC-33509, OPC33509, K134)

生物&药学活性

物理化学性质&存储条件

参考文献

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PDE3 inhibitor K-134 (OPC-33509, OPC33509, K134)

生物&药学活性

物理化学性质&存储条件

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