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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-MK-0873
MK-0873

Chemical Structure : MK-0873

CAS No.: 500355-52-2

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MK-0873 (MK0873)

货号: PC-28123Not For Human Use, Lab Use Only.

MK-0873 is a potent and orally active phosphodiesterase 4 (PDE4) inhibitor with IC50 of 6.7 nM (PDE4A), inhibits LPS-induced TNF-α production in human whole blood with IC50 of 178 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

MK-0873 is a potent and orally active phosphodiesterase 4 (PDE4) inhibitor with IC50 of 6.7 nM (PDE4A), inhibits LPS-induced TNF-α production in human whole blood with IC50 of 178 nM.

物理化学性质&存储条件

分子量 422.44
分子式 C25H18N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((3-(3-(cyclopropylcarbamoyl)-4-oxo-1,8-naphthyridin-1(4H)-yl)phenyl)ethynyl)pyridine 1-oxide

参考文献

1. Guay D, et al. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5554-8.

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