| Cat. No. |
Product Name |
Information |
| PC-28482 |
Philanthotoxin-74
GluA2-containing AMPARs antagonist
|
Philanthotoxin-74 (PhTx-74) is a specific antagonist of GluA2-containing AMPARs, inhibiting GluR1/2, but not GluR2/3 receptors, inhibits homomeric GluA1 and GluA3 receptors nonselectively with IC50 in the nanomolar range (252-356 nM), and heteromeric GluA1/A2 and GluA2/A3 receptors nonselectively, with IC50 in the micromolar range (22 μM). |
| PC-28480 |
JNJ-56022486
TARP-γ8 modulator
|
JNJ-56022486 is a potent, selective and orally active negative AMPA receptor modulator with Ki of 18 nM for transmembrane AMPA receptor regulatory protein γ8 (TARP-γ8, CACNG8). |
| PC-28147 |
gamma-Glu-Gly
NMDA GluN1/mGlu5 agonist
|
γ-Glutamyl-Glycine (γ-Glu-Gly) is a a glutathione metabolite and seletive partial agonist of NMDA GluN1 and mGlu5 receptors, with no bindding for glutamate binding domain on both AMPA and NMDA GluN2A receptors, triggers a long-term increase in synaptic transmission in the CA1 area of mouse hippocampus. |
| PC-27687 |
GluN2B-NMDAR antagonist-1
GluN2B antagonist
|
GluN2B-NMDAR antagonist-1 (Compound Z25) is a selective GluN2B subunit-containing NMDA receptor antagonist, inhibits Ca2+ influx induced by NMDA. |
| PC-27552 |
GYKI-53655
AMPAR antagonist
|
GYKI-53655 (GYKI 53655, LY300168) is a non-competitive AMPA receptor antagonist with IC50 of 5.9 uM. |
| PC-26348 |
Otefprodil
GluN2B antagonist
|
Otefprodil is a potent, selective antagonist of NR2B (GluN2B)-containing NMDA receptors, inhibits glutamic acid and glycine induced activation. |
| PC-26280 |
EU1180-560
GluN1/GluN3A antagonist
|
EU1180-560 is a subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor with IC50 of 2.6 uM, with no detectable effect on GluN1/GluN3B receptors. |
| PC-26279 |
EU1180-590
GluN1/GluN3A antagonist
|
EU1180-590 is a brain penetrant, subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor with IC50 of 3.7 uM, with no detectable effect on GluN1/GluN3B receptors. |
| PC-26196 |
EVT-101
GluN2B antagonist
|
EVT-101 is a highly potent, selective and orally active GluN2B antagonist with IC50 of 12 nM for GluN1/GluN2B. |
| PC-26121 |
UCM-A86
GluN3 NMDA receptor PAM
|
UCM-A86 is a selective positive allosteric modulator (PAM) of GluN1/GluN3 NMDA receptors with EC50 of 21 μM and 19 μM at GluN1/GluN3A and GluN1/GluN3B receptors, respectively, selective over GluN1/GluN2A-D receptors. |
| PC-25963 |
FP802 hydrochloride
TwinF interface inhibitor
|
FP802 hydrochloride is a potent neuroprotectant and small molecule inhibitor of TwinF interface, shows selective elimination of eNMDAR-mediated toxicity via disruption of the NMDAR/TRPM4 death signaling complex, while sparing the vital physiological functions of synaptic NMDARs. |
| PC-25186 |
GluN2A PAM Y36
GluN2A PAM
|
GluN2A PAM Y36 is a potent, GluN2A-selective N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulator with EC50 of 24.97 uM, Emax=397.7%. |
