| Cat. No. |
Product Name |
Information |
| PC-23270 |
CX1763
AMPAR modulator
|
CX1763 is an allosteric modulator of AMPA receptor, enhances synaptic transmission in hippocampi of rats. |
| PC-23086 |
Nevadistinel
NMDAR PAM
|
Nevadistinel (NYX-458, NYX-3054) is a positive allosteric modulator of the N-methyl-D-aspartate (NMDA) receptor. |
| PC-22610 |
NS3763
GLUK5 antagonist
|
NS3763 is a noncompetitive antagonist of GLUK5 receptor, inhibits domoate-induced increase in intracellular calcium mediated through the GLU(K5) of kainate receptors with IC50 of 1.6 uM, with no effect on GLU(K6) subtype. |
| PC-22609 |
3-Hydroxykynurenine
iGluR modulator
|
3-Hydroxykynurenine (3-HK) is a metabolite produced through host tryptophan metabolism, restricts bacterial expansion in macrophages via a systemic mechanism, modulates the activity of iGluR receptors of the AMPAR and KAR subclasses. |
| PC-22608 |
Rapastinel trifluoroacetate
NMDAR agonist
|
Rapastinel (GLYX-13, Thr-Pro-Pro-Thr-NH2) trifluoroacetateis a tetrapeptide (TPPT-amide) that acts as a NMDA receptor glycine site partial agonist. |
| PC-22455 |
FS2921
GluN1/GluN2A NMDAR PAM
|
FS2921 is a potential, functionally selective GluN1/GluN2A positive allosteric modulator (PAM), selective versus GluN1/GluN2B and GluN1/GluN2D, increases NMDAR-mediated currents with EC50 of 8.8 uM. |
| PC-22454 |
GNE-6901
GluN2A PAM
|
GNE-6901 is a selective GluN2A containing NMDAR positive allosteric modulator (PAM) wIth EC50 of 382 nM, binds to the GluN1/GluN2A LBD dimer interface. |
| PC-22453 |
GNE-8324
GluN2A PAM
|
GNE-8324 is a selective GluN2A containing NMDAR positive allosteric modulator (PAM), binds to the GluN1/GluN2A LBD dimer interface. |
| PC-22451 |
MPX-007
GluN2A antagonist
|
MPX-007 is a selective GluN2A antagonist, inhibits GluN2A-containing NMDA receptors expressed in HEK cells with IC50 of 27 nM. |
| PC-22449 |
TCN213
GluN2A antagonist
|
TCN213 is a selective, glycine-dependently GluN2A-containing NMDARs antagonist with IC50 of 0.55 uM for GluN1/GluN2A NMDAR, negligible effect on GluN1/GluN2B NMDA receptor. |
| PC-22425 |
CX1739
AMPAR modulator
|
CX1739 is a small molecule AMPAR allosteric modulator. |
| PC-22159 |
HU-210
NMDAR antagonist
|
HU-211 is a functional N-methyl-D-aspartate receptor blocker with IC50 of 6-10 uM for glutamate- or glycine-induced binding. |
