| Cat. No. |
Product Name |
Information |
| PC-26194 |
EU93-31
GluN2B antagonist
|
EU93-31 is a potent, pH-sensitive GluN2B-selective antagonist of NMDA receptor with IC50 of 0.19 uM (GluN1/GluN2B, pH=6.9) and 1.8 uM (GluN1/GluN2B, pH=7.6). |
| PC-26193 |
EU93-108
GluN2B NAM
|
EU93-108 is a potent, brain penetrant GluN2B-selective negative allosteric modulator (NAM) of NMDA receptor with IC50 of 0.557 uM (GluN1/GluN2B), with limited activity against GluN1/GluN2A, GluN1/GluN2C and GluN1/GluN2D |
| PC-26192 |
UCM-101
GluN2A NAM
|
UCM-101 is a potent, selective negative allosteric modulator of GluN2A-containing NMDA receptors with IC50 of 0.11 uM for GluN1/2A, 17-, 35-, and 118-fold selective for GluN1/2A over GluN1/2B, GluN1/2C, and GluN1/2D receptors, respectively. |
| PC-25808 |
Radiprodil
GluN2B antagonist
|
Radiprodil (RGH-896) is a selective, negative allosteric modulator / antagonist of GluN2B-containing NMDA receptors (GluN2B) with IC50 of 3-10 nM, with no activity against NR2A receptors. |
| PC-25676 |
Fanapanel
AMPA antagonist
|
Fanapanel (ZK200775) is a highly selective AMPA/kainate antagonis with Ki values of 3.2 nM, 100 nM, and 8.5 μM against quisqualate, kainate, and NMDA, respectively. |
| PC-25185 |
GNE-3419
GluN2A PAM
|
GNE-3419 is a potent, GluN2A-selective NMDA receptor (NMDAR) positive allosteric modulator with EC50 of 1.9 uM, Emax=150%, 10-fold lower with GluN2D. |
| PC-24115 |
Blixeprodil
NMDAR antagonist
|
Blixeprodil (GM-1020) is a selective NMDA receptor (NMDAR) antagonist, displaces [3H]MK-801 binding to NMDAR in rat cortical tissue with Ki of 3.25 uM. |
| PC-23906 |
HZS60
NMDAR/TRPM4 inhibitor
|
HZS60 is a specific NMDAR/TRPM4 interaction interface inhibitor, displays significant neuroprotective effects against both NMDA and oxygen-glucose deprivation/reoxygenation-induced ischemic injury in primary neurons. |
| PC-23690 |
SYM2081
GluK2 agonist
|
SYM2081 is a potent, specific agonist of glutamate receptor ionotropic kainate 2 (GluK2) with EC50 of 0.2 uM, inhibits inhibits [3H]-kainate binding with IC50 of 35 nM. |
| PC-23363 |
Lanicemine dihydrochloride
NMDAR antagonist
|
Lanicemine dihydrochloride (AZD6765, ARL-15896) is a low-trapping NMDA channel blocker with Ki of 0.56-2.1 μM, IC50 of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, shows antidepressant effects. |
| PC-23362 |
Lanicemine
NMDAR antagonist
|
Lanicemine (AZD6765, ARL-15896) is a low-trapping NMDA channel blocker with Ki of 0.56-2.1 μM, IC50 of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, shows antidepressant effects. |
| PC-23271 |
CX1942
AMPAR modulator
|
CX1763 is an allosteric modulator of AMPA receptor, enhances synaptic transmission in hippocampi of rats. |
