GNE-3419 | GluN2A PAM | Probechem Biochemicals

Chemical Structure : GNE-3419

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货号: PC-25185Not For Human Use, Lab Use Only.

GNE-3419 is a potent, GluN2A-selective NMDA receptor (NMDAR) positive allosteric modulator with EC50 of 1.9 uM, Emax=150%, 10-fold lower with GluN2D.

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GNE-3419 is a potent, GluN2A-selective NMDA receptor (NMDAR) positive allosteric modulator with EC50 of 1.9 uM, Emax=150%, 10-fold lower with GluN2D.

分子量	300.38
分子式	C15H16N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-((ethyl(phenyl)amino)methyl)-2-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

1. Volgraf M, et al. J Med Chem. 2016 Mar 24;59(6):2760-79.

2. Tzu-Ming Wang, et al. Neuropharmacology. 2017 Jul 15:121:204-218.

3. David H Hackos, et al. Neuron. 2016 Mar 2;89(5):983-99.