| Cat. No. |
Product Name |
Information |
| PC-28341 |
Pregnanolone sulfate pyridinium
NMDA receptor inhibitor
|
Pregnanolone sulfate pyridinium (PregS) is an endogenous neurosteroid that inhibits NMDA receptors, acts as a cognitive enhancer and modulator of neurotransmission. |
| PC-27572 |
IEM-1754
GluR2-lacking AMPAR antagonist
|
IEM-1754 is a selective antagonist of GluR2-lacking AMPA receptors (AMPAR) with KD of 12.0 uM (−80 mV), has >80-fold selectivity over GluR2-containing AMPAR. |
| PC-27571 |
IEM-1925
GluR2-lacking AMPAR antagonist
|
IEM-1925 is a selective antagonist of GluR2-lacking AMPA receptors (AMPAR) with KD of 1.1 uM (−80 mV), >100-fold selective over GluR2-containing AMPAR. |
| PC-27551 |
UBP310
Kainate receptor antagoist
|
UBP310 is a high affinity, selective antagonist of kainate receptor GluR5 with Kd of 130 nM, has >800-fold selecitvity over GluR2 and GluR6, binds to GluK1 with KD of 21 nM, but shows no specific binding to GluK2. |
| PC-27330 |
GluN2A NAM 6a
GluN2A inhibitor
|
GluN2A NAM 6a is a potent, selective nonsulfonamide GluN2A negative allosteric modulator / inhibitor with IC50 of 3.91 uM, with no activity against GluN2B/C/D. |
| PC-27283 |
CX717
AMPAR PAM
|
CX717 is a positive allosteric modulator of AMPA receptors, prevents opiate-induced respiratory depression, shows antidepressant activities. |
| PC-26935 |
Memantine
NMDA receptor antagonist
|
Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist with Ki of 0.19 uM for competing with [3H]MK-801 binding in membrane homogenates of postmortem human frontal cortex. |
| PC-26837 |
Fluoroethylnormemantine
NMDA receptor antagonist
|
Fluoroethylnormemantine (FENM) is a structural analogue of Memantine and NMDA receptor antagonist with Ki of 3.5 uM, exhibits anti-amnesic, neuroprotective, antidepressant-like and fear-attenuating effects. |
| PC-26281 |
CGP-78608 hydrochloride
GluN1 antagonist
|
CGP 78608 hydrochloride is a highly potent and selective antagonist of GluN1/GluN3 NMDAR, antagonizes GluN1/GluN2 receptors, acts as an ultra-potent and powerful potentiator of GluN1/GluN3A receptors. |
| PC-26278 |
EU1180-438
GluN1/GluN3 receptor antagonist
|
EU1180-438 is potent, selective GluN1/GluN3 receptor negative allosteric modulator (NAM) / antagonist with IC50 of 3.5 uM, highly selective over GluN1/GluN2 NMDA receptors, AMPA, and kainate receptors. |
| PC-26197 |
GluN2B antagonist 22
GluN2B antagonist
|
GluN2B antagonist 22 (MK-22) is a highly potent, GluN2B (NR2B)-selective NMDA receptor antagonist with IC50/Ki of 1.0 nM and 0.88 nM, respectively. |
| PC-26195 |
R-(+)-EU-1180-453
GluN2C/D PAM
|
R-(+)-EU-1180-453 is a potent, second-generation GluN2C/D-selective NMDAR-positive allosteric modulator (PAM), with no effect on GluN1/GluN2A and GluN1/GluN2B. |
