EU1180-438

Chemical Structure : EU1180-438

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货号: PC-26278Not For Human Use, Lab Use Only.

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生物&药学活性

EU1180-438 is potent, selective GluN1/GluN3 receptor negative allosteric modulator (NAM) / antagonist with IC50 of 3.5 uM, highly selective over GluN1/GluN2 NMDA receptors, AMPA, and kainate receptors.
EU1180-438 is also inactive at GABA, glycine, and P2X receptors, but displays inhibition of some nicotinic acetylcholine receptors.
EU1180-438 inhibits neuronal responses mediated by GluN3A-containing receptors.
EU1180-438 can inhibit GluN1/GluN3A responses during activity-dependent or ischemia-dependent changes in extracellular pH.
EU1180-438 activity is independent of membrane potential and agonist concentration.

物理化学性质&存储条件

分子量	389.45
分子式	C24H23NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(4-methoxyphenoxy)-1-(4-methoxyphenyl)ethyl)isoindolin-1-one

参考文献

1. Zongjian Zhu, et al. Neuropharmacology. 2020 Oct 1:176:108117.

EU1180-438

生物&药学活性

物理化学性质&存储条件

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EU1180-438

生物&药学活性

物理化学性质&存储条件

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