| Cat. No. |
Product Name |
Information |
| PC-25090 |
Satoprodil
GluN2B NAM
|
Satoprodil (BI 1569912) is a potent, oral, selective negative allosteric modulator (NAM) of GluN2B subunit-containing NMDA receptors. |
| PC-24631 |
JNJ-78911118
GluN2A antagonist
|
JNJ-78911118 is a potent, centrally-penetrant, selective antagonist of GluN2A-containing NMDA receptors, blocks GluN1/2AR-induced calcium flux with IC50 of 46 nM. |
| PC-24489 |
Riluzole
Glutamate modulator, TPC2 agonist
|
Riluzole is an anticonvulsant agent and N-methyl-D-aspartate (NMDA) glutamate receptor blocker, also is a TPC2 activator, also inhibits Kv4.2, Kv4.2/DPP6, and Kv4.2/KChIP2c channels in a voltage-independent manner. |
| PC-23361 |
MPX-004
GluN2A antagonist
|
MPX-004 is a potent, GluN2A-selective negative allosteric modulator and NMDA antagonist with IC50 of 78 nM for inhibition of Ca2+ responses mediated by GluN2A receptors expressed in HEK cells. |
| PC-23317 |
MDL-29951
GPR17 agonist, NMDAR antagonist
|
MDL-29951 (MDL-29, 951) is a potent glycine antagonist of NMDA receptor with Ki of 0.14 uM for [3H]glycine binding in vitro, also is a potent GPR17 agonist with pEC50 of 6.48. |
| PC-23269 |
EU1622-240
NMDAR PAM
|
EU1622-240 is a positive allosteric modulator of NMDA receptors (NMDARs), preferentially potentiate GluN2B-, GluN2C-, and GluN2D-containing NMDARs with EC50 of 0.57 uM, 0.82 uM and 1.1 uM respectively. |
| PC-23082 |
Risevistinel
NMDAR PAM
|
Risevistinel (NYX-783, NYX783) is a potent, specific N-methyl-D-aspartate receptor (NMDAR) positive allosteric-modulator. |
| PC-22452 |
Apimostinel
NMDAR agonist
|
Apimostinel (NRX-1074; AGN-241660) is a potential, orally active antidepressant and NMDAR partial agonist. |
| PC-22450 |
TCN201
GluN2A antagonist
|
TCN201 (TCN-201) is a selective GluN2A-containing NMDARs antagonist with pIC50 of 6.8 uM for GluN1/GluN2A NMDAR, negligible effect on GluN1/GluN2B NMDA receptor. |
| PC-22292 |
TAK-653
AMPAR PAM
|
TAK-653 (NBI-1065845, Osavampator) is a potent, selective AMPA receptor positive allosteric modulator/potentiator, induces Ca2+ influx in hGluA1i CHO cells with EC50 of 2.2 uM. |
| PC-22280 |
Ro 25-6981
GluN2B antagonist
|
Ro 25-6981 is a potent and selective antagonist of NMDA receptors containing NR2B (GluN2B) subunit with IC50 of 3 nM for inhibition 3H-MK-801 binding to rat forebrain membranes. |
| PC-22279 |
Ro 25-6981 maleate
NMDA NR2B inhibitor
|
Ro 25-6981 maleate is a potent and selective antagonist of NMDA receptors containing NR2B (GluN2B) subunits with IC50 of 3 nM for inhibition 3H-MK-801 binding to rat forebrain membranes. |
