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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-EU93-108
EU93-108

Chemical Structure : EU93-108

CAS No.: 1097212-18-4

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EU93-108

货号: PC-26193Not For Human Use, Lab Use Only.

EU93-108 is a potent, brain penetrant GluN2B-selective negative allosteric modulator (NAM) of NMDA receptor with IC50 of 0.557 uM (GluN1/GluN2B), with limited activity against GluN1/GluN2A, GluN1/GluN2C and GluN1/GluN2D

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

EU93-108 is a potent, brain penetrant GluN2B-selective negative allosteric modulator (NAM) of NMDA receptor with IC50 of 0.557 uM (GluN1/GluN2B), with limited activity against GluN1/GluN2A, GluN1/GluN2C and GluN1/GluN2D.

物理化学性质&存储条件

分子量 441.49
分子式 C20H25F2N3O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-N-(4-(3-(4-(3,4-difluorophenyl)piperazin-1-yl)-2-hydroxypropoxy)phenyl)methanesulfonamide

参考文献

1. Harris LD, et al. ACS Chem Neurosci. 2023 Mar 1;14(5):917-935.

2. Yuan H, et al. Neuron. 2015 Mar 18;85(6):1305-1318.

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