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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-UCM-101
UCM-101

Chemical Structure : UCM-101

CAS No.:

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UCM-101 (UCM101)

货号: PC-26192Not For Human Use, Lab Use Only.

UCM-101 is a potent, selective negative allosteric modulator of GluN2A-containing NMDA receptors with IC50 of 0.11 uM for GluN1/2A, 17-, 35-, and 118-fold selective for GluN1/2A over GluN1/2B, GluN1/2C, and GluN1/2D receptors, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

UCM-101 is a potent, selective negative allosteric modulator of GluN2A-containing NMDA receptors with IC50 of 0.11 uM for GluN1/2A, 17-, 35-, and 118-fold selective for GluN1/2A over GluN1/2B, GluN1/2C, and GluN1/2D receptors, respectively.
UCM-101 inhibits NMDA receptor-mediated excitatory postsynaptic currents (EPSCs) in CA1 pyramidal neurons.
UCM-101 inhibits NMDA receptors by negatively modulating co-agonist binding to the GluN1 subunit via an allosteric mechanism that is conserved with previously described GluN2A-selective antagonists, TCN-201 and MPX-004. 

物理化学性质&存储条件

分子量 404.59
分子式 C20H28N4OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-N-(cyclohexylmethyl)-2-((5-((1-phenylpropyl)amino)-1,3,4-thiadiazol-2-yl)thio)acetamide

参考文献

1. Lotti JS, et al. J Gen Physiol. 2026 Jan 5;158(1):e202513872.

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