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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-EU1180-560
EU1180-560

Chemical Structure : EU1180-560

CAS No.: 2677758-09-5

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EU1180-560

货号: PC-26280Not For Human Use, Lab Use Only.

EU1180-560 is a subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor with IC50 of 2.6 uM, with no detectable effect on GluN1/GluN3B receptors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    EU1180-560 is a subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor with IC50 of 2.6 uM, with no detectable effect on GluN1/GluN3B receptors.
    EU1180-560 produce noncompetitive, voltage-independent inhibition, consistent with a negative allosteric modulation mechanism.
    EU1180-560 shows little to no effect on GluN1/GluN2-containing NMDA, AMPA, GABA, glycine, P2X, and kainate receptors.

    物理化学性质&存储条件

    分子量 435.50
    分子式 C26H26FNO4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-fluoro-2-(1-(4-isopropoxyphenyl)-2-(4-methoxyphenoxy)ethyl)isoindolin-1-one

    参考文献

    1. Jacobs L, et al. Mol Pharmacol. 2026 Jan 29;108(3):100104.

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