EU1180-560

Chemical Structure : EU1180-560

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货号: PC-26280Not For Human Use, Lab Use Only.

EU1180-560 is a subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor with IC50 of 2.6 uM, with no detectable effect on GluN1/GluN3B receptors.

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生物&药学活性

EU1180-560 is a subunit-selective negative allosteric modulator of GluN1/GluN3A glycine-activated receptor with IC50 of 2.6 uM, with no detectable effect on GluN1/GluN3B receptors.
EU1180-560 produce noncompetitive, voltage-independent inhibition, consistent with a negative allosteric modulation mechanism.
EU1180-560 shows little to no effect on GluN1/GluN2-containing NMDA, AMPA, GABA, glycine, P2X, and kainate receptors.

物理化学性质&存储条件

分子量	435.50
分子式	C26H26FNO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-fluoro-2-(1-(4-isopropoxyphenyl)-2-(4-methoxyphenoxy)ethyl)isoindolin-1-one

参考文献

1. Jacobs L, et al. Mol Pharmacol. 2026 Jan 29;108(3):100104.

EU1180-560

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EU1180-560

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物理化学性质&存储条件

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