FP802 hydrochloride

Chemical Structure : FP802 hydrochloride

CAS No.: 2490401-57-3

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货号: PC-25963Not For Human Use, Lab Use Only.

规格	价格	库存
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

FP802 hydrochloride is a potent neuroprotectant and small molecule inhibitor of TwinF interface, shows selective elimination of eNMDAR-mediated toxicity via disruption of the NMDAR/TRPM4 death signaling complex, while sparing the vital physiological functions of synaptic NMDARs.
FP802 displays potent protective activity against glutamate-mediated neurotoxicity with IC50 of 8.7 uM for analysis of the percentage of nuclear mCherry-positive neurons.
FP802 eliminates the transcriptional shut-off induced by eNMDARs and boosts the NMDA bath application-induced expression of the immediate-early genes (IEGs) Atf3, Arc, Bdnf, cFos, Inhibin beta A, and Npas4.
FP802 does not not block NMDARs expressed heterologously in HEK293 cells (IC50 > 250 μM for both, GluN1/GluN2A and GluN1/GluN2B).
FP802 (40 mg/kg/day) improves motor performances, extends lifespan, and prevents motor neuron loss in SOD1G93A mice.
FP802 protects human brain organoids generated using iPSCs from ALS patients or healthy controls against NMDA-induced neurotoxicity.

物理化学性质&存储条件

分子量	285.64
分子式	C11H19Cl3N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(3-Chlorobenzyl)-N1-ethylethane-1,2-diamine dihydrochloride

参考文献

1. Jing Yan, et al. Cell Rep Med. 2024 Feb 20;5(2):101413.