Philanthotoxin-74 (PhTx-74) | GluA2-containing AMPARs antagonist

Chemical Structure : Philanthotoxin-74

CAS No.: 1227301-51-0

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Philanthotoxin-74 (Philanthotoxin 74, PhTx-74)

货号: PC-28482Not For Human Use, Lab Use Only.

Philanthotoxin-74 (PhTx-74) is a specific antagonist of GluA2-containing AMPARs, inhibiting GluR1/2, but not GluR2/3 receptors, inhibits homomeric GluA1 and GluA3 receptors nonselectively with IC50 in the nanomolar range (252-356 nM), and heteromeric GluA1/A2 and GluA2/A3 receptors nonselectively, with IC50 in the micromolar range (22 μM).

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

Philanthotoxin-74 (PhTx-74) is a specific antagonist of GluA2-containing AMPARs, inhibiting GluR1/2, but not GluR2/3 receptors, inhibits homomeric GluA1 and GluA3 receptors nonselectively with IC50 in the nanomolar range (252-356 nM), and heteromeric GluA1/A2 and GluA2/A3 receptors nonselectively, with IC50 in the micromolar range (22 μM).

物理化学性质&存储条件

分子量	507.54
分子式	C24H44Cl2N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-alpha-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride

参考文献

1. Poulsen MH, et al. Mol Pharmacol. 2014 Feb;85(2):261-8.

2. Kromann H, et al. J Med Chem. 2002;45:5745–5754.

3. Aaron Nilsen, et al. J Am Chem Soc. 2007 Apr 25;129(16):4902-3.

Philanthotoxin-74 (Philanthotoxin 74, PhTx-74)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

Philanthotoxin-74 (Philanthotoxin 74, PhTx-74)

生物&药学活性

物理化学性质&存储条件

参考文献

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