| Cat. No. |
Product Name |
Information |
| PC-27043 |
DBK-766
PP2A activator
|
DBK-766 is a nonfunctional small molecule activator of PP2A (SMAP), binds to subunit PR65. |
| PC-27019 |
SDUY104
SHP2 inhibitor
|
SDUY104 is a potent, selective, allosteric SHP2 inhibitor with enzymatic IC50 of 0.14 uM. |
| PC-27018 |
SDUY038
SHP2 inhibitor
|
SDUY038 is a potent, selective, allosteric SHP2 inhibitor with high binding affinity (KD=0.29 uM), enzymatic IC50 of 1.2 uM. |
| PC-26846 |
SDUY127
SHP2 inhibitor
|
SDUY127 is a potent, bivalent, allosteric inhibitor of SHP2 (PTPN11) with IC50 of 16 nM, exhibits antiproliferative efficacy against MV4-11 cells through suppression of MAPK signaling. |
| PC-26204 |
SHP1 inhibitor M029
SHP1 inhibitor
|
SHP1 inhibitor M029 is a covalent, allosteric SHP1 inhibitor with IC50 of 2.6 uM, covalently targets cryptic Cys480 far away from the active site. |
| PC-26136 |
Pimecrolimus
Calcineurin inhibitor
|
Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active calcineurin inhibitor with Ki of 117 nM, shows anti-inflammatory activity. |
| PC-26115 |
SHP1 agonist SCA9
SHP1 agonist
|
SHP1 agonist SCA9 is a highly selective covalent agonist of SHP1 (SHP-1) targeting Cys102, binds the N-SH2 domain to relieve autoinhibition and activate SHP1 with EC50 of 13.4 uM. |
| PC-26016 |
ATUX-8385
PP2A activator
|
ATUX-8385 is a tricyclic sulfonamide PP2A activator, interacts PP2A scaffold subunit PR65, decreases viability, proliferation, and motility of NB cells. |
| PC-25950 |
Alexidine dihydrochloride
PTPMT1 inhibitor
|
Alexidine dihydrochloride is an anticancer agent that targets mitochondrial tyrosine phosphatase PTPMT1, induces mitochondrial apoptosis, also is a TAZ-TEAD binding inhibitor capable of suppressing TAZ-induced migration and invasion in breast cancer cells. |
| PC-25843 |
PTPN2/1 inhibitor WS35
Dual PTPN2/N1 inhibitor
|
PTPN2/1 inhibitor WS35 is potent dual PTPN2 (TCPTP) / PTPN1 inhibitor with IC50 of 5.8 /12.8 nM respectively. |
| PC-25789 |
RPT04402
PP2A molecular glue
|
RPT04402 is a PP2A molecular glue that selectively stabilizes PP2A-B56α heterotrimers. |
| PC-25611 |
PRLthiophenib
PRL-3 inhibitor
|
PRLthiophenib is a potent, selective inhibitor of phosphatase of regenerating liver 3 (PRL-3, PRL3) with IC50 of 7.8 uM, shows mucher weaker inhibitor for PRL-1 and -2 (IC50=31 uM and 15.8 uM), binds directly to PRL-3 with Kd of 23 uM. |
