SHP2 inhibitor 17g

Chemical Structure : SHP2 inhibitor 17g

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货号: PC-27065Not For Human Use, Lab Use Only.

SHP2 inhibitor 17g is a potent and selective allosteric SHP2 inhibitor with IC50 of 49 nM (SHP2 WT).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

SHP2 inhibitor 17g is a potent and selective allosteric SHP2 inhibitor with IC50 of 49 nM (SHP2 WT).
SHP2 inhibitor 17g also effectively suppresses ERK phosphorylation in MV-4-11, Panc-1, and KYSE520 cells with an IC50 of 50, 250, and 410 nM, respectively.
SHP2 inhibitor 17g shows limited activity against the isolated catalytic PTP domain of SHP2.
SHP2 inhibitor 17g exhibits growth inhibition with IC50 of 70 nM for MV-4-11 cells.

物理化学性质&存储条件

分子量	480.40
分子式	C24H23Cl2N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1'-(3-amino-2-(2,3-dichlorophenyl)-2H-pyrazolo[3,4-b]pyrazin-6-yl)-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine

参考文献

1. Amoussa M, et al. ChemMedChem. 2026 Jun 15;21(11):e70341.