| Cat. No. |
Product Name |
Information |
| PC-72973 |
DIPQUO
Alkaline phosphatase activator
|
DIPQUO is a small molecule activator of the bone marker alkaline phosphatase (ALP) expression with EC50 of 6.27 uM, p38-β mediate DIQPUO-driven osteoblast differentiation effect. |
| PC-72803 |
MPK5 inhibitor 1
MKP5 inhibitor
|
MPK5 inhibitor 1 (MPK5-IN-1, DUSP10 inhibitor compound 1) is a potent, selective allosteric inhibitor of MAPK phosphatase MKP5 (DUSP10) with Kd/IC50 of 1.0/3.9 uM. |
| PC-72611 |
PF-07284892
SHP2 inhibitor
|
PF-07284892 (ARRY-558) is a potent, selective allosteric SHP2 inhibitor with IC50 of 21 nM, has 1,000-fold selectivity for SHP2 over 21 other phosphatases, including the closely related SHP1. |
| PC-72527 |
SMIP-30
PPM1A inhibitor
|
SMIP-30 is a potent and selective inhibitor of PPM1A with IC50 of 1 uM, selectively inhibits the phosphatase activity of PPM1A. |
| PC-72526 |
SCP1 inhibitor T-62
SCP1 inhibitor
|
SCP1 inhibitor T-62 (T-62) is a specific, small molecule covalent inhibitor of small CTD phosphatase 1 (SCP1), reduces transcription factor REST protein level HEK293 cells. |
| PC-72524 |
SCP1 inhibitor T-65
SCP1 inhibitor
|
SCP1 inhibitor T-65 (T-65) is a specific, small molecule covalent inhibitor of small CTD phosphatase 1 (SCP1), reduces transcription factor REST protein level HEK293 cells with EC50 of 1.5 uM. |
| PC-72461 |
MLS000544460
EYA2 inhibitor
|
MLS000544460 (EYA2i) is a specific, allosteric inhibitor of Eya2 phosphatase with IC50 of 4.1 uM, KD of 2.0 uM, does not bind Eya3 ED, Eya1 and Eya4 ED. |
| PC-72452 |
NCGC00249987
EYA2 inhibitor
|
NCGC00249987 (Compound 9987) is a small-molecule allosteric inhibitor that specifically inhibits the Tyr phosphatase activity of EYA2 with IC50 of 3.1 uM (Eya2 ED), but not other Eya family members. |
| PC-72451 |
NCGC00378430
SIX1-EYA2 inhibitor
|
NCGC00378430 (Compound 8430) is a novel small molecule compound that reduces the SIX1/EYA2 interaction in vitro with IC50 of 52 uM in the Alphascreen assay. |
| PC-72326 |
TK-453
SHP2 inhibitor
|
TK-453 (TK453) is a potent, selective SHP2 allosteric inhibitor with IC50 of 18.76 and 179 nM for SHP2-WT and SHP2-E76K, respectively. |
| PC-72034 |
PTPN22 inhibitor L-1
PTPN22 inhibitor
|
PTPN22 inhibitor L-1 (PTPN22-IN-1) is a selective, competitive small molecule inhibitor of PTPN22 with IC50 of 1.4 uM, Ki of 0.5 uM, 7- to 10-fold selectivity for PTPN22 over 16 similar PTPs. |
| PC-72033 |
CNBDA
SHP2 inhibitor
|
CNBDA is a novel selective Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitor with IC50 of 5 uM, 25-fold selectivity over SHP1. |
