| Cat. No. |
Product Name |
Information |
| PC-21454 |
AS1938909
SHIP2 inhibitor
|
AS1938909 is a potent, selective and competitive SHIP2 inhibitor with Ki value of 0.44 uM (human SHIP2), shows significant selectivity over other related phosphatases. |
| PC-21366 |
ATUX-1215
PP2A activator
|
ATUX-1215 is a direct, orally active small molecule activator of protein phosphatase 2A (PP2A), suppresses bleomycin-induced fibrosis in vivo. |
| PC-21359 |
ATUX-792
PP2A activator
|
ATUX-792 is a small molecule activator of protein phosphatase 2A (PP2A), decreases survival, proliferation, and motility of neuroblastoma in vitro and tumor growth in vivo. |
| PC-21296 |
PP5 inhibitor P053
PP5 inhibitor
|
PP5 inhibitor P053 (Compound P053) is a potent, selective and competitive inhibitor of serine/threonine protein phosphatase-5 (PP5) with Ki of 244 nM, specifically binds and inhibits PP5 activity. |
| PC-21074 |
PTPN22 inhibitor NC1
PTPN22 inhibitor
|
PTPN22 inhibitor NC1 is a specific, noncompetitive, allosteric PTPN22 (lymphoid-specific tyrosine phosphatase, LYP) inhibitor with Ki of 4.3 uM, effectively and specifically inhibits LYP-mediated TCR signaling in T cells. |
| PC-20996 |
E7/PTPN14 inhibitor compound 20
HPV E7-PTPN14 inhibitor
|
E7/PTPN14 inhibitor compound 20 (F0470-0212) is a first-in-class inhibitor of PPI of HPV E7 oncoprotein and the cellular phosphatase PTPN14 (E7/PTPN14 interaction) with IC50 of 4.7 uM in ELISA-based assays, selectively affects the viability of HPV-positive cervical cancer cells. |
| PC-20969 |
Compound 182
PTP1B/PTPN2 inhibitor
|
Compound 182 is a highly potent and selective active site competitive inhibitor of PTP1B and PTPN2, inhibits the catalytic activities of PTP1B and PTPN2 with IC50 of 0.63 and 0.58 nM, respectively. |
| PC-20911 |
SHP-1 agonist SC-43
SHP-1 agonist
|
SHP-1 agonist SC-43 is a potent and orally active SHP-1 (PTPN6) agonist, SC-43 interacts with the N-SH2 domain of SHP-1 to enhance the activity of SHP-1. |
| PC-20711 |
SBI-221
SHP2-E76K inhibitor
|
SBI-221 is a small molecule inhihitor of SHP2-E76K mutant with IC50 of 2.1 uM and 7.4 uM for SHP2-E76K and SHP2-WT in isothermal CETSA assays, respectively. |
| PC-20470 |
PTP1B inhibitor BDB
PTP1B inhibitor
|
PTP1B inhibitor BDB is a natural compound found in marine red algaea, is a selective, cell‐permeable and competitive inhibitor of PTP1B with IC50 of 1.86 uM. |
| PC-20469 |
PTP1B inhibitor BBR
PTP1B inhibitor
|
PTP1B inhibitor BBR is a selective, non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B with IC50 of 8 uM. |
| PC-20365 |
HN252
PPM1B inhibitor
|
HN252 is a potent protein phosphatase 1B (PPM1B) inhibitor with Ki of 0.52 uM and IC50 of 0.76 uM, shows no inhibition against topoisomerases in vitro. |
