欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-ATUX-1215
ATUX-1215

Chemical Structure : ATUX-1215

CAS No.: 2910930-01-5

加入收藏

ATUX-1215 (ATUX1215)

货号: PC-21366Not For Human Use, Lab Use Only.

ATUX-1215 is a direct, orally active small molecule activator of protein phosphatase 2A (PP2A), suppresses bleomycin-induced fibrosis in vivo.

规格 价格 库存 数量
5 mg ￥2880 In stock
10 mg ￥4580 In stock
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

ATUX-1215 is a direct, orally active small molecule activator of protein phosphatase 2A (PP2A), suppresses bleomycin-induced fibrosis in vivo.
ATUX-1215 (1 uM) induces PP2A phosphatase activity responses in fibroblasts, reduced the level of TGFβ induction of ACTA2, COL1A1, COL1A2, and FN1 gene expression in fibroblasts.
ATUX-1215 activates PP2A responses in the BLM model and elicited potentially useful therapeutic effects.
ATUX-1215 (5 mg/kg, daily, oral) reduces the BLM-induced BALF levels of IL12p70, GM-CSF, and IL-1α in C57BL/6J mice.
ATUX-1215 shows the improved metabolic stability and bioavailability of ATUX-1215 to previously described PP2A activators.
ATUX-1215 prevents BLM-induced lung physiology changes, including the preservation of normal PV loop, compliance, tissue elastance, and forced vital capacity.

物理化学性质&存储条件

分子量 553.54
分子式 C27H24F5NO4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzenesulfonamide, N-[(2R,4S)-2-(2,8-difluoro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)tetrahydro-2H-pyran-4-yl]-4-(trifluoromethoxy)-

参考文献

1. Meshach Pillai, et al. ACS Pharmacol Transl Sci. 2023 Oct 17;6(11):1659-1672.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: