| Cat. No. |
Product Name |
Information |
| PC-47481 |
Microcystin-LR
PP2A inhibitor
|
Microcystin-LR (MC-LR) is a potent, selective inhibitor of protein phosphatase 2A (PP2A) with IC50 of 0.04 nM. |
| PC-45526 |
CPDA
SHIP2 inhibitor
|
CPDA is a potent SHIP2 inhibitor that enhances in vitro insulin signaling through the Akt pathway more efficiently than AS1949490, and ameliorates abnormal glucose metabolism in diabetic (db/db) mice. |
| PC-45470 |
LB-100
PP2A inhibitor
|
LB-100 (LB100) is a potent serine/threonine protein phosphatase 2A (PP2A) inhibitor. |
| PC-42304 |
NQ301
CD45 inhibitor
|
NQ301 (CD45 inhibitor 211, Compound 211) is a potent antithrombotic agent that inhibits thromboxane A2 receptor and synthase activity, also is a potent, selective inhibitor of CD45 tyrosine phosphatase with IC50 of 200 nM. |
| PC-42166 |
TPI-1
SHP-1 inhibitor
|
TPI-1 is a potent and selective, orally-active protein tyrosine phosphatases SHP-1 inhibitor with IC50 of 40 nM (0.01 ug/ml). |
| PC-42207 |
Stibogluconate sodium
PTPs inhibitor
|
Stibogluconate sodium (Sodium stibogluconate) is a multiple antimony compound that has leishmanicidal and potential antineoplastic activities, inhibits protein tyrosine phosphorylase SHP-1 (99% inhibtion at 10 ug/mL), SHP-2 and PTP1B, shows anticancer activity in synergy with IFNs. |
| PC-45510 |
LTV-1
PTPN22 inhibitor
|
LTV-1 is a highly potent, cell-permeable and reversible LYP (lymphoid tyrosine phosphatase, PTPN22) inhibitor with IC50 of 508 nM. |
| PC-42696 |
PTP1B-IN-1
PTP1B inhibitor
|
PTP1B-IN-1 is a 1,2,5-thiadiazolidin-3-one-1,1-dioxide scaffold for design of protein tyrosine phosphatase-1B (PTP1B) inhibitor, shows weak inhibition for PTP1B with IC50 of 1.6 mM. |
| PC-26846 |
SDUY127
SHP2 inhibitor
|
SDUY127 is a potent, bivalent, allosteric inhibitor of SHP2 (PTPN11) with IC50 of 16 nM, exhibits antiproliferative efficacy against MV4-11 cells through suppression of MAPK signaling. |
| PC-26204 |
SHP1 inhibitor M029
SHP1 inhibitor
|
SHP1 inhibitor M029 is a covalent, allosteric SHP1 inhibitor with IC50 of 2.6 uM, covalently targets cryptic Cys480 far away from the active site. |
| PC-26136 |
Pimecrolimus
Calcineurin inhibitor
|
Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active calcineurin inhibitor with Ki of 117 nM, shows anti-inflammatory activity. |
| PC-26115 |
SHP1 agonist SCA9
SHP1 agonist
|
SHP1 agonist SCA9 is a highly selective covalent agonist of SHP1 (SHP-1) targeting Cys102, binds the N-SH2 domain to relieve autoinhibition and activate SHP1 with EC50 of 13.4 uM. |
