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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-SDUY038
SDUY038

Chemical Structure : SDUY038

CAS No.: 2892720-11-3

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SDUY038 (SDUY-038)

货号: PC-27018Not For Human Use, Lab Use Only.

SDUY038 is a potent, selective, allosteric SHP2 inhibitor with high binding affinity (KD=0.29 uM), enzymatic IC50 of 1.2 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SDUY038 is a potent, selective, allosteric SHP2 inhibitor with high binding affinity (KD=0.29 uM), enzymatic IC50 of 1.2 uM.
SDUY038 exhibits pan-antitumor activity (IC50=7-24 μM) by suppressing pERK expression.
SDUY038 significantly inhibited tumor growth in both xenograft and organoid models.

物理化学性质&存储条件

分子量 385.30
分子式 C17H18Cl2N2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-amino-4-methylpiperidin-1-yl)(5-((2,3-dichlorophenyl)thio)furan-2-yl)methanone

参考文献

1. Zhu C, et al. J Med Chem. 2024 Aug 8;67(15):13305-13323.

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