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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-SDUY104
SDUY104

Chemical Structure : SDUY104

CAS No.:

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SDUY104 (SDUY-104)

货号: PC-27019Not For Human Use, Lab Use Only.

SDUY104 is a potent, selective, allosteric SHP2 inhibitor with enzymatic IC50 of 0.14 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SDUY104 is a potent, selective, allosteric SHP2 inhibitor with enzymatic IC50 of 0.14 uM.
SDUY104 significantly impaired the proliferation of KRAS-driven pancreatic cancer cells by inducing cell-cycle arrest and apoptosis.
SDUY104 suppressed MAPK signaling while triggering compensatory PI3K-AKT activation.
Combining SDUY104 with ERK inhibitor Ulixertinib produced synergistic antiproliferative activity via enhanced MAPK suppression. Combination of SDUY104 with PI3K inhibitor BKM-120 exhibited superior antitumor activity compared to either monotherapy in PANC-1 xenograft model.

物理化学性质&存储条件

分子量 453.99
分子式 C24H24ClN3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-(1-amino-1,3-dihydrospiro[indene-2,4'-piperidin]-1'-yl)(5-((3-amino-2-chlorophenyl)thio)furan-2-yl)methanone

参考文献

1. Zhu C, et al. J Med Chem. 2026 Jun 9. doi: 10.1021/acs.jmedchem.6c00836.

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